The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites

Many enzymes make “mistakes”. Consequently, repair enzymes have evolved to correct these mistakes. For example, lactate dehydrogenase (LDH) and mitochondrial malate dehydrogenase (mMDH) slowly catalyze the reduction of 2-oxoglutarate (2-OG) to the oncometabolite l-2-hydroxyglutarate (l-2-HG). l-2-HG...

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Detalles Bibliográficos
Autores principales: Hariharan, Vivek A., Denton, Travis T., Paraszcszak, Sarah, McEvoy, Kyle, Jeitner, Thomas M., Krasnikov, Boris F., Cooper, Arthur J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485471/
https://www.ncbi.nlm.nih.gov/pubmed/28358347
http://dx.doi.org/10.3390/biology6020024

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