Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test
BACKGROUND: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of defi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485500/ https://www.ncbi.nlm.nih.gov/pubmed/28651626 http://dx.doi.org/10.1186/s12993-017-0129-0 |
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author | Wang, Yi-quan Pan, Yang Zhu, Sheng Wang, Yong-guang Shen, Zhi-hua Wang, Kai |
author_facet | Wang, Yi-quan Pan, Yang Zhu, Sheng Wang, Yong-guang Shen, Zhi-hua Wang, Kai |
author_sort | Wang, Yi-quan |
collection | PubMed |
description | BACKGROUND: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the study was to identify whether the HIV-infected patients showed a specific attention network deficit or a general attentional impairment. METHODS: We investigated 27 HIV-infected patients and 31 normal controls with the Attention Network Test (ANT). RESULTS: The patients exhibited less efficient alerting network and executive network than controls. No significant difference was found in orienting network effect between groups. Our results also indicate a tendency for poorer efficiency on alerting attention and executive attention in patients with CD4 ≤ 200. CONCLUSIONS: Our findings suggest that HIV-infected patients exhibited selective impairments of attention network of alerting and executive control. The link between lower CD4 T cell count and poorer attention network function imply the importance of starting antiretroviral therapy earlier to avoid irreversible neurocognitive impairment. |
format | Online Article Text |
id | pubmed-5485500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54855002017-06-30 Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test Wang, Yi-quan Pan, Yang Zhu, Sheng Wang, Yong-guang Shen, Zhi-hua Wang, Kai Behav Brain Funct Research BACKGROUND: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the study was to identify whether the HIV-infected patients showed a specific attention network deficit or a general attentional impairment. METHODS: We investigated 27 HIV-infected patients and 31 normal controls with the Attention Network Test (ANT). RESULTS: The patients exhibited less efficient alerting network and executive network than controls. No significant difference was found in orienting network effect between groups. Our results also indicate a tendency for poorer efficiency on alerting attention and executive attention in patients with CD4 ≤ 200. CONCLUSIONS: Our findings suggest that HIV-infected patients exhibited selective impairments of attention network of alerting and executive control. The link between lower CD4 T cell count and poorer attention network function imply the importance of starting antiretroviral therapy earlier to avoid irreversible neurocognitive impairment. BioMed Central 2017-06-27 /pmc/articles/PMC5485500/ /pubmed/28651626 http://dx.doi.org/10.1186/s12993-017-0129-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Wang, Yi-quan Pan, Yang Zhu, Sheng Wang, Yong-guang Shen, Zhi-hua Wang, Kai Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test |
title | Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test |
title_full | Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test |
title_fullStr | Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test |
title_full_unstemmed | Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test |
title_short | Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test |
title_sort | selective impairments of alerting and executive control in hiv-infected patients: evidence from attention network test |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485500/ https://www.ncbi.nlm.nih.gov/pubmed/28651626 http://dx.doi.org/10.1186/s12993-017-0129-0 |
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