Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

BACKGROUND: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of defi...

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Autores principales: Wang, Yi-quan, Pan, Yang, Zhu, Sheng, Wang, Yong-guang, Shen, Zhi-hua, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485500/
https://www.ncbi.nlm.nih.gov/pubmed/28651626
http://dx.doi.org/10.1186/s12993-017-0129-0
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author Wang, Yi-quan
Pan, Yang
Zhu, Sheng
Wang, Yong-guang
Shen, Zhi-hua
Wang, Kai
author_facet Wang, Yi-quan
Pan, Yang
Zhu, Sheng
Wang, Yong-guang
Shen, Zhi-hua
Wang, Kai
author_sort Wang, Yi-quan
collection PubMed
description BACKGROUND: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the study was to identify whether the HIV-infected patients showed a specific attention network deficit or a general attentional impairment. METHODS: We investigated 27 HIV-infected patients and 31 normal controls with the Attention Network Test (ANT). RESULTS: The patients exhibited less efficient alerting network and executive network than controls. No significant difference was found in orienting network effect between groups. Our results also indicate a tendency for poorer efficiency on alerting attention and executive attention in patients with CD4 ≤ 200. CONCLUSIONS: Our findings suggest that HIV-infected patients exhibited selective impairments of attention network of alerting and executive control. The link between lower CD4 T cell count and poorer attention network function imply the importance of starting antiretroviral therapy earlier to avoid irreversible neurocognitive impairment.
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spelling pubmed-54855002017-06-30 Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test Wang, Yi-quan Pan, Yang Zhu, Sheng Wang, Yong-guang Shen, Zhi-hua Wang, Kai Behav Brain Funct Research BACKGROUND: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the study was to identify whether the HIV-infected patients showed a specific attention network deficit or a general attentional impairment. METHODS: We investigated 27 HIV-infected patients and 31 normal controls with the Attention Network Test (ANT). RESULTS: The patients exhibited less efficient alerting network and executive network than controls. No significant difference was found in orienting network effect between groups. Our results also indicate a tendency for poorer efficiency on alerting attention and executive attention in patients with CD4 ≤ 200. CONCLUSIONS: Our findings suggest that HIV-infected patients exhibited selective impairments of attention network of alerting and executive control. The link between lower CD4 T cell count and poorer attention network function imply the importance of starting antiretroviral therapy earlier to avoid irreversible neurocognitive impairment. BioMed Central 2017-06-27 /pmc/articles/PMC5485500/ /pubmed/28651626 http://dx.doi.org/10.1186/s12993-017-0129-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Wang, Yi-quan
Pan, Yang
Zhu, Sheng
Wang, Yong-guang
Shen, Zhi-hua
Wang, Kai
Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test
title Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test
title_full Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test
title_fullStr Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test
title_full_unstemmed Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test
title_short Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test
title_sort selective impairments of alerting and executive control in hiv-infected patients: evidence from attention network test
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485500/
https://www.ncbi.nlm.nih.gov/pubmed/28651626
http://dx.doi.org/10.1186/s12993-017-0129-0
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