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Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission

BACKGROUND: The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother’s fecal/vaginal microbiota and human milk. RESULTS: The composition...

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Autores principales: Duranti, Sabrina, Lugli, Gabriele Andrea, Mancabelli, Leonardo, Armanini, Federica, Turroni, Francesca, James, Kieran, Ferretti, Pamela, Gorfer, Valentina, Ferrario, Chiara, Milani, Christian, Mangifesta, Marta, Anzalone, Rosaria, Zolfo, Moreno, Viappiani, Alice, Pasolli, Edoardo, Bariletti, Ilaria, Canto, Rosarita, Clementi, Rosanna, Cologna, Marina, Crifò, Tiziana, Cusumano, Giuseppina, Fedi, Sabina, Gottardi, Stefania, Innamorati, Claudia, Masè, Caterina, Postai, Daniela, Savoi, Daniela, Soffiati, Massimo, Tateo, Saverio, Pedrotti, Anna, Segata, Nicola, van Sinderen, Douwe, Ventura, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485682/
https://www.ncbi.nlm.nih.gov/pubmed/28651630
http://dx.doi.org/10.1186/s40168-017-0282-6
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author Duranti, Sabrina
Lugli, Gabriele Andrea
Mancabelli, Leonardo
Armanini, Federica
Turroni, Francesca
James, Kieran
Ferretti, Pamela
Gorfer, Valentina
Ferrario, Chiara
Milani, Christian
Mangifesta, Marta
Anzalone, Rosaria
Zolfo, Moreno
Viappiani, Alice
Pasolli, Edoardo
Bariletti, Ilaria
Canto, Rosarita
Clementi, Rosanna
Cologna, Marina
Crifò, Tiziana
Cusumano, Giuseppina
Fedi, Sabina
Gottardi, Stefania
Innamorati, Claudia
Masè, Caterina
Postai, Daniela
Savoi, Daniela
Soffiati, Massimo
Tateo, Saverio
Pedrotti, Anna
Segata, Nicola
van Sinderen, Douwe
Ventura, Marco
author_facet Duranti, Sabrina
Lugli, Gabriele Andrea
Mancabelli, Leonardo
Armanini, Federica
Turroni, Francesca
James, Kieran
Ferretti, Pamela
Gorfer, Valentina
Ferrario, Chiara
Milani, Christian
Mangifesta, Marta
Anzalone, Rosaria
Zolfo, Moreno
Viappiani, Alice
Pasolli, Edoardo
Bariletti, Ilaria
Canto, Rosarita
Clementi, Rosanna
Cologna, Marina
Crifò, Tiziana
Cusumano, Giuseppina
Fedi, Sabina
Gottardi, Stefania
Innamorati, Claudia
Masè, Caterina
Postai, Daniela
Savoi, Daniela
Soffiati, Massimo
Tateo, Saverio
Pedrotti, Anna
Segata, Nicola
van Sinderen, Douwe
Ventura, Marco
author_sort Duranti, Sabrina
collection PubMed
description BACKGROUND: The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother’s fecal/vaginal microbiota and human milk. RESULTS: The composition of bifidobacterial communities of 25 mother-infant pairs was investigated based on an internal transcribed spacer (ITS) approach, combined with cultivation-mediated and genomic analyses. We identified bifidobacterial strains/communities that are shared between mothers and their corresponding newborns. Notably, genomic analyses together with growth profiling assays revealed that bifidobacterial strains that had been isolated from human milk are genetically adapted to utilize human milk glycans. In addition, we identified particular bacteriophages specific of bifidobacterial species that are common in the viromes of mother and corresponding child. CONCLUSIONS: This study highlights the transmission of bifidobacterial communities from the mother to her child and implies human milk as a potential vehicle to facilitate this acquisition. Furthermore, these data represent the first example of maternal inheritance of bifidobacterial phages, also known as bifidophages in infants following a vertical transmission route. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40168-017-0282-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-54856822017-06-30 Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission Duranti, Sabrina Lugli, Gabriele Andrea Mancabelli, Leonardo Armanini, Federica Turroni, Francesca James, Kieran Ferretti, Pamela Gorfer, Valentina Ferrario, Chiara Milani, Christian Mangifesta, Marta Anzalone, Rosaria Zolfo, Moreno Viappiani, Alice Pasolli, Edoardo Bariletti, Ilaria Canto, Rosarita Clementi, Rosanna Cologna, Marina Crifò, Tiziana Cusumano, Giuseppina Fedi, Sabina Gottardi, Stefania Innamorati, Claudia Masè, Caterina Postai, Daniela Savoi, Daniela Soffiati, Massimo Tateo, Saverio Pedrotti, Anna Segata, Nicola van Sinderen, Douwe Ventura, Marco Microbiome Research BACKGROUND: The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother’s fecal/vaginal microbiota and human milk. RESULTS: The composition of bifidobacterial communities of 25 mother-infant pairs was investigated based on an internal transcribed spacer (ITS) approach, combined with cultivation-mediated and genomic analyses. We identified bifidobacterial strains/communities that are shared between mothers and their corresponding newborns. Notably, genomic analyses together with growth profiling assays revealed that bifidobacterial strains that had been isolated from human milk are genetically adapted to utilize human milk glycans. In addition, we identified particular bacteriophages specific of bifidobacterial species that are common in the viromes of mother and corresponding child. CONCLUSIONS: This study highlights the transmission of bifidobacterial communities from the mother to her child and implies human milk as a potential vehicle to facilitate this acquisition. Furthermore, these data represent the first example of maternal inheritance of bifidobacterial phages, also known as bifidophages in infants following a vertical transmission route. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40168-017-0282-6) contains supplementary material, which is available to authorized users. BioMed Central 2017-06-26 /pmc/articles/PMC5485682/ /pubmed/28651630 http://dx.doi.org/10.1186/s40168-017-0282-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Duranti, Sabrina
Lugli, Gabriele Andrea
Mancabelli, Leonardo
Armanini, Federica
Turroni, Francesca
James, Kieran
Ferretti, Pamela
Gorfer, Valentina
Ferrario, Chiara
Milani, Christian
Mangifesta, Marta
Anzalone, Rosaria
Zolfo, Moreno
Viappiani, Alice
Pasolli, Edoardo
Bariletti, Ilaria
Canto, Rosarita
Clementi, Rosanna
Cologna, Marina
Crifò, Tiziana
Cusumano, Giuseppina
Fedi, Sabina
Gottardi, Stefania
Innamorati, Claudia
Masè, Caterina
Postai, Daniela
Savoi, Daniela
Soffiati, Massimo
Tateo, Saverio
Pedrotti, Anna
Segata, Nicola
van Sinderen, Douwe
Ventura, Marco
Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
title Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
title_full Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
title_fullStr Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
title_full_unstemmed Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
title_short Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
title_sort maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485682/
https://www.ncbi.nlm.nih.gov/pubmed/28651630
http://dx.doi.org/10.1186/s40168-017-0282-6
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