Cargando…

Evidence for an early innate immune response in the motor cortex of ALS

BACKGROUND: Recent evidence indicates the importance of innate immunity and neuroinflammation with microgliosis in amyotrophic lateral sclerosis (ALS) pathology. The MCP1 (monocyte chemoattractant protein-1) and CCR2 (CC chemokine receptor 2) signaling system has been strongly associated with the in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jara, Javier H., Genç, Barış, Stanford, Macdonell J., Pytel, Peter, Roos, Raymond P., Weintraub, Sandra, Mesulam, M. Marsel, Bigio, Eileen H., Miller, Richard J., Özdinler, P. Hande
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485686/ https://www.ncbi.nlm.nih.gov/pubmed/28651542 http://dx.doi.org/10.1186/s12974-017-0896-4

Ejemplares similares

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS
por: Genç, Barış, et al.
Publicado: (2017)

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
por: Jara, Javier H., et al.
Publicado: (2019)

The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord
por: Genc, Baris, et al.
Publicado: (2020)

Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease
por: Jara, Javier H., et al.
Publicado: (2014)

Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function
por: Jara, Javier H., et al.
Publicado: (2015)

Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons
por: Genc, Baris, et al.
Publicado: (2019)

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons
por: Genç, Barış, et al.
Publicado: (2022)

Absence of UCHL 1 function leads to selective motor neuropathy
por: Genç, Barış, et al.
Publicado: (2016)

Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD(+) balance as a therapeutic strategy
por: Gautam, Mukesh, et al.
Publicado: (2022)

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS
por: Dervishi, Ina, et al.
Publicado: (2018)

Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex
por: Jara, J H, et al.
Publicado: (2016)

The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS
por: Jara, Javier H., et al.
Publicado: (2020)

A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance
por: Genç, Barış, et al.
Publicado: (2004)

Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology
por: Martersteck, Adam, et al.
Publicado: (2022)

NU-9 improves health of hSOD1(G93A) mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone
por: Genç, Barış, et al.
Publicado: (2022)

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms
por: Gautam, Mukesh, et al.
Publicado: (2016)

Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line
por: Genç, Barış, et al.
Publicado: (2015)

Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer’s disease
por: Ohm, Daniel T., et al.
Publicado: (2020)

Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS
por: Gautam, Mukesh, et al.
Publicado: (2019)

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology
por: Genç, Barış, et al.
Publicado: (2021)

Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories
por: Gefen, Tamar, et al.
Publicado: (2019)

Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS
por: Gozutok, Oge, et al.
Publicado: (2021)

Primary progressive aphasia: a dementia of the language network
por: Mesulam, Marsel
Publicado: (2013)

Primary Progressive Aphasia and the Left Hemisphere Language Network
por: Mesulam, M. Marsel
Publicado: (2016)

Clinical and neuropathological features of ALS/FTD with TIA1 mutations
por: Hirsch-Reinshagen, Veronica, et al.
Publicado: (2017)

Associations of MAP2K3 Gene Variants With Superior Memory in SuperAgers
por: Huentelman, Matthew J., et al.
Publicado: (2018)

Verbal and Nonverbal Memory in Primary Progressive Aphasia: The Three Words-Three Shapes Test
por: Weintraub, Sandra, et al.
Publicado: (2013)

Syntactic and Morphosyntactic Processing in Stroke-Induced and Primary Progressive Aphasia
por: Thompson, Cynthia K., et al.
Publicado: (2013)

FUS Interacts with HSP60 to Promote Mitochondrial Damage
por: Deng, Jianwen, et al.
Publicado: (2015)

Differential vulnerability of the dentate gyrus to tauopathies in dementias
por: Kawles, Allegra, et al.
Publicado: (2023)

Hippocampal subfield surface deformity in nonsemantic primary progressive aphasia
por: Christensen, Adam, et al.
Publicado: (2015)

German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia
por: Ditges, Ruth, et al.
Publicado: (2021)

Complementary feature selection from alternative splicing events and gene expression for phenotype prediction
por: Labuzzetta, Charles J, et al.
Publicado: (2016)

2-Year-Old and 3-Year-Old Italian ALS Patients with Novel ALS2 Mutations: Identification of Key Metabolites in Their Serum and Plasma
por: Gautam, Mukesh, et al.
Publicado: (2022)

A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction
por: Lopez, Ana, et al.
Publicado: (2017)

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
por: Wang, Peng, et al.
Publicado: (2019)

Communication Bridge™-2 (CB2): an NIH Stage 2 randomized control trial of a speech-language intervention for communication impairments in individuals with mild to moderate primary progressive aphasia
por: Roberts, Angela C., et al.
Publicado: (2022)

Psychological well-being in elderly adults with extraordinary episodic memory
por: Cook Maher, Amanda, et al.
Publicado: (2017)

Thematic Integration Impairments in Primary Progressive Aphasia: Evidence From Eye-Tracking
por: Walenski, Matthew, et al.
Publicado: (2021)

Quantitative patterns of motor cortex proteinopathy across ALS genotypes
por: Nolan, Matthew, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_su98m5i176c9si2sikjilife4u