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Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China
BACKGROUND: The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use under modified drug administration guidelines. METHODS: In total, 1389 ADR cases we...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485713/ https://www.ncbi.nlm.nih.gov/pubmed/28651624 http://dx.doi.org/10.1186/s40360-017-0159-0 |
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author | Fang, Huan Lin, Xiaowen Zhang, Jun Hong, Zhen Sugiyama, Kenji Nozaki, Takao Sameshima, Tetsuro Kobayashi, Susumu Namba, Hiroki Asakawa, Tetsuya |
author_facet | Fang, Huan Lin, Xiaowen Zhang, Jun Hong, Zhen Sugiyama, Kenji Nozaki, Takao Sameshima, Tetsuro Kobayashi, Susumu Namba, Hiroki Asakawa, Tetsuya |
author_sort | Fang, Huan |
collection | PubMed |
description | BACKGROUND: The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use under modified drug administration guidelines. METHODS: In total, 1389 ADR cases were reviewed. Cases were divided into two groups, cases from period 1 (n = 557, from January 2006 to June 2011) under the old SR system and cases in period 2 (n = 832, from July 2011 to December 2016) under the new SR system with multiple interventions to improve physician SR compliance. General information, drug information, and clinical manifestations were investigated and compared between periods. RESULTS: Interventions for improved clinician training, education on knowledge, attitudes, and practices (KAP), and economic incentives substantially improved SR adherence. We also found that changing drug usage patterns (based on the new drug administration guidelines) greatly influenced ADR occurrence and type. CONCLUSIONS: We found the SR compliance can be improved by multifaceted interventions. Drug usage patterns also influence ADR occurrence, so programs tailored for rational use are essential. These results could lead to further improvements in the SR system for ADRs in China, and provide guidance for establishing better methods of pharmacovigilance. |
format | Online Article Text |
id | pubmed-5485713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54857132017-06-30 Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China Fang, Huan Lin, Xiaowen Zhang, Jun Hong, Zhen Sugiyama, Kenji Nozaki, Takao Sameshima, Tetsuro Kobayashi, Susumu Namba, Hiroki Asakawa, Tetsuya BMC Pharmacol Toxicol Research Article BACKGROUND: The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use under modified drug administration guidelines. METHODS: In total, 1389 ADR cases were reviewed. Cases were divided into two groups, cases from period 1 (n = 557, from January 2006 to June 2011) under the old SR system and cases in period 2 (n = 832, from July 2011 to December 2016) under the new SR system with multiple interventions to improve physician SR compliance. General information, drug information, and clinical manifestations were investigated and compared between periods. RESULTS: Interventions for improved clinician training, education on knowledge, attitudes, and practices (KAP), and economic incentives substantially improved SR adherence. We also found that changing drug usage patterns (based on the new drug administration guidelines) greatly influenced ADR occurrence and type. CONCLUSIONS: We found the SR compliance can be improved by multifaceted interventions. Drug usage patterns also influence ADR occurrence, so programs tailored for rational use are essential. These results could lead to further improvements in the SR system for ADRs in China, and provide guidance for establishing better methods of pharmacovigilance. BioMed Central 2017-06-26 /pmc/articles/PMC5485713/ /pubmed/28651624 http://dx.doi.org/10.1186/s40360-017-0159-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Fang, Huan Lin, Xiaowen Zhang, Jun Hong, Zhen Sugiyama, Kenji Nozaki, Takao Sameshima, Tetsuro Kobayashi, Susumu Namba, Hiroki Asakawa, Tetsuya Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China |
title | Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China |
title_full | Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China |
title_fullStr | Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China |
title_full_unstemmed | Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China |
title_short | Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China |
title_sort | multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485713/ https://www.ncbi.nlm.nih.gov/pubmed/28651624 http://dx.doi.org/10.1186/s40360-017-0159-0 |
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