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MicroRNA as Therapeutic Targets for Chronic Wound Healing

Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of...

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Detalles Bibliográficos
Autores principales: Mulholland, Eoghan J., Dunne, Nicholas, McCarthy, Helen O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485763/
https://www.ncbi.nlm.nih.gov/pubmed/28918046
http://dx.doi.org/10.1016/j.omtn.2017.06.003
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author Mulholland, Eoghan J.
Dunne, Nicholas
McCarthy, Helen O.
author_facet Mulholland, Eoghan J.
Dunne, Nicholas
McCarthy, Helen O.
author_sort Mulholland, Eoghan J.
collection PubMed
description Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways. Thus, identification of the appropriate miR involved in the different phases of wound healing could reveal an effective third-generation genetic therapy in chronic wound care. Several miRs have been shown to be upregulated or downregulated during the wound healing process. This article examines the biological processes involved in wound healing, the miR involved at each stage, and how expression levels are modulated in the chronic wound environment. Key miRs are highlighted as possible therapeutic targets, either through underexpression or overexpression, and the healing benefits are interrogated. These are prime miR candidates that could be considered as a gene therapy option for patients suffering from chronic wounds. The success of miR as a gene therapy, however, is reliant on the development of an appropriate delivery system that must be designed to overcome both extracellular and intracellular barriers.
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spelling pubmed-54857632017-07-10 MicroRNA as Therapeutic Targets for Chronic Wound Healing Mulholland, Eoghan J. Dunne, Nicholas McCarthy, Helen O. Mol Ther Nucleic Acids Review Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways. Thus, identification of the appropriate miR involved in the different phases of wound healing could reveal an effective third-generation genetic therapy in chronic wound care. Several miRs have been shown to be upregulated or downregulated during the wound healing process. This article examines the biological processes involved in wound healing, the miR involved at each stage, and how expression levels are modulated in the chronic wound environment. Key miRs are highlighted as possible therapeutic targets, either through underexpression or overexpression, and the healing benefits are interrogated. These are prime miR candidates that could be considered as a gene therapy option for patients suffering from chronic wounds. The success of miR as a gene therapy, however, is reliant on the development of an appropriate delivery system that must be designed to overcome both extracellular and intracellular barriers. American Society of Gene & Cell Therapy 2017-06-09 /pmc/articles/PMC5485763/ /pubmed/28918046 http://dx.doi.org/10.1016/j.omtn.2017.06.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Mulholland, Eoghan J.
Dunne, Nicholas
McCarthy, Helen O.
MicroRNA as Therapeutic Targets for Chronic Wound Healing
title MicroRNA as Therapeutic Targets for Chronic Wound Healing
title_full MicroRNA as Therapeutic Targets for Chronic Wound Healing
title_fullStr MicroRNA as Therapeutic Targets for Chronic Wound Healing
title_full_unstemmed MicroRNA as Therapeutic Targets for Chronic Wound Healing
title_short MicroRNA as Therapeutic Targets for Chronic Wound Healing
title_sort microrna as therapeutic targets for chronic wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485763/
https://www.ncbi.nlm.nih.gov/pubmed/28918046
http://dx.doi.org/10.1016/j.omtn.2017.06.003
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