Cargando…
School‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in Hong Kong
BACKGROUND: Influenza imposes substantial healthcare burden in children, which can be prevented by vaccination. Influenza vaccination coverage varies widely among childhood populations worldwide, which has significant impact on herd immunity and usefulness of influenza vaccine. However, there are li...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485870/ https://www.ncbi.nlm.nih.gov/pubmed/28444974 http://dx.doi.org/10.1111/irv.12455 |
_version_ | 1783246153215639552 |
---|---|
author | Leung, Ting F. Chan, Renee W. Y. Kwok, Angela Ho, Wendy C. S. Tao, Mars K. P. Hon, Kam L. Cheng, Frankie W. T. Li, Albert M. Chan, Paul K. S. |
author_facet | Leung, Ting F. Chan, Renee W. Y. Kwok, Angela Ho, Wendy C. S. Tao, Mars K. P. Hon, Kam L. Cheng, Frankie W. T. Li, Albert M. Chan, Paul K. S. |
author_sort | Leung, Ting F. |
collection | PubMed |
description | BACKGROUND: Influenza imposes substantial healthcare burden in children, which can be prevented by vaccination. Influenza vaccination coverage varies widely among childhood populations worldwide, which has significant impact on herd immunity and usefulness of influenza vaccine. However, there are limited real‐life data on influenza vaccine effectiveness (VE) in children. OBJECTIVE: This prospective study aimed to investigate clinical spectrum of childhood influenza and VE in preventing influenza in Hong Kong children. METHODS: A total of 623 children were recruited from 15 kindergartens and primary schools. Parents completed a questionnaire on subjects’ health and influenza vaccination history. Flocked nasopharyngeal swabs (FNPSs) were collected in biweekly school visits during 2014‐2015 influenza seasons. Influenza A and B viruses were detected and typed by molecular assays. RESULTS: A total of 2633 FNPS samples were collected, with two or more samples being obtained from 607 (97.4%) of subjects. Thirty‐six (11.2%) subjects had influenza A or B in 2014, whereas all 19 (6.3%) subjects identified in 2015 had influenza A. Ninety‐nine subjects reported influenza‐like illness (ILI), and nine illness visits were arranged. Influenza vaccination was protective against ILI but not mild laboratory‐confirmed influenza by surveillance. Moderate overall influenza VE of 42%‐52% was observed for ILI, and subgroup analyses showed much higher VE for both ILI (70.9% vs 34.6%) and mild laboratory‐confirmed influenza (44.0% vs −6.2%) in school‐age children than preschoolers who were vaccinated within 12 months. CONCLUSIONS: Mild laboratory‐confirmed influenza infection is common in children during influenza seasons. Influenza vaccination is effective against ILI but not mild infection identified by surveillance. |
format | Online Article Text |
id | pubmed-5485870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54858702017-07-04 School‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in Hong Kong Leung, Ting F. Chan, Renee W. Y. Kwok, Angela Ho, Wendy C. S. Tao, Mars K. P. Hon, Kam L. Cheng, Frankie W. T. Li, Albert M. Chan, Paul K. S. Influenza Other Respir Viruses Original Articles BACKGROUND: Influenza imposes substantial healthcare burden in children, which can be prevented by vaccination. Influenza vaccination coverage varies widely among childhood populations worldwide, which has significant impact on herd immunity and usefulness of influenza vaccine. However, there are limited real‐life data on influenza vaccine effectiveness (VE) in children. OBJECTIVE: This prospective study aimed to investigate clinical spectrum of childhood influenza and VE in preventing influenza in Hong Kong children. METHODS: A total of 623 children were recruited from 15 kindergartens and primary schools. Parents completed a questionnaire on subjects’ health and influenza vaccination history. Flocked nasopharyngeal swabs (FNPSs) were collected in biweekly school visits during 2014‐2015 influenza seasons. Influenza A and B viruses were detected and typed by molecular assays. RESULTS: A total of 2633 FNPS samples were collected, with two or more samples being obtained from 607 (97.4%) of subjects. Thirty‐six (11.2%) subjects had influenza A or B in 2014, whereas all 19 (6.3%) subjects identified in 2015 had influenza A. Ninety‐nine subjects reported influenza‐like illness (ILI), and nine illness visits were arranged. Influenza vaccination was protective against ILI but not mild laboratory‐confirmed influenza by surveillance. Moderate overall influenza VE of 42%‐52% was observed for ILI, and subgroup analyses showed much higher VE for both ILI (70.9% vs 34.6%) and mild laboratory‐confirmed influenza (44.0% vs −6.2%) in school‐age children than preschoolers who were vaccinated within 12 months. CONCLUSIONS: Mild laboratory‐confirmed influenza infection is common in children during influenza seasons. Influenza vaccination is effective against ILI but not mild infection identified by surveillance. John Wiley and Sons Inc. 2017-05-25 2017-07 /pmc/articles/PMC5485870/ /pubmed/28444974 http://dx.doi.org/10.1111/irv.12455 Text en © 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Leung, Ting F. Chan, Renee W. Y. Kwok, Angela Ho, Wendy C. S. Tao, Mars K. P. Hon, Kam L. Cheng, Frankie W. T. Li, Albert M. Chan, Paul K. S. School‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in Hong Kong |
title | School‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in Hong Kong |
title_full | School‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in Hong Kong |
title_fullStr | School‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in Hong Kong |
title_full_unstemmed | School‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in Hong Kong |
title_short | School‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in Hong Kong |
title_sort | school‐based surveillance for influenza vaccine effectiveness during 2014‐2015 seasons in hong kong |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485870/ https://www.ncbi.nlm.nih.gov/pubmed/28444974 http://dx.doi.org/10.1111/irv.12455 |
work_keys_str_mv | AT leungtingf schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong AT chanreneewy schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong AT kwokangela schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong AT howendycs schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong AT taomarskp schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong AT honkaml schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong AT chengfrankiewt schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong AT lialbertm schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong AT chanpaulks schoolbasedsurveillanceforinfluenzavaccineeffectivenessduring20142015seasonsinhongkong |