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The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis

The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. Activating mutatio...

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Detalles Bibliográficos
Autores principales: Tsapogas, Panagiotis, Mooney, Ciaran James, Brown, Geoffrey, Rolink, Antonius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485939/
https://www.ncbi.nlm.nih.gov/pubmed/28538663
http://dx.doi.org/10.3390/ijms18061115
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author Tsapogas, Panagiotis
Mooney, Ciaran James
Brown, Geoffrey
Rolink, Antonius
author_facet Tsapogas, Panagiotis
Mooney, Ciaran James
Brown, Geoffrey
Rolink, Antonius
author_sort Tsapogas, Panagiotis
collection PubMed
description The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. Activating mutations of Flt3 are frequently found in acute myeloid leukemia (AML) patients and associated with a poor clinical prognosis. In the present review we provide an overview of our current knowledge on the role of FL in the generation of blood cell lineages. We examine recent studies on Flt3 expression by hematopoietic stem cells and its potential instructive action at early stages of hematopoiesis. In addition, we review current findings on the role of mutated FLT3 in leukemia and the development of FLT3 inhibitors for therapeutic use to treat AML. The importance of mouse models in elucidating the role of Flt3-ligand in normal and malignant hematopoiesis is discussed.
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spelling pubmed-54859392017-06-29 The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis Tsapogas, Panagiotis Mooney, Ciaran James Brown, Geoffrey Rolink, Antonius Int J Mol Sci Review The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. Activating mutations of Flt3 are frequently found in acute myeloid leukemia (AML) patients and associated with a poor clinical prognosis. In the present review we provide an overview of our current knowledge on the role of FL in the generation of blood cell lineages. We examine recent studies on Flt3 expression by hematopoietic stem cells and its potential instructive action at early stages of hematopoiesis. In addition, we review current findings on the role of mutated FLT3 in leukemia and the development of FLT3 inhibitors for therapeutic use to treat AML. The importance of mouse models in elucidating the role of Flt3-ligand in normal and malignant hematopoiesis is discussed. MDPI 2017-05-24 /pmc/articles/PMC5485939/ /pubmed/28538663 http://dx.doi.org/10.3390/ijms18061115 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tsapogas, Panagiotis
Mooney, Ciaran James
Brown, Geoffrey
Rolink, Antonius
The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis
title The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis
title_full The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis
title_fullStr The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis
title_full_unstemmed The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis
title_short The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis
title_sort cytokine flt3-ligand in normal and malignant hematopoiesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485939/
https://www.ncbi.nlm.nih.gov/pubmed/28538663
http://dx.doi.org/10.3390/ijms18061115
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