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Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or d...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485962/ https://www.ncbi.nlm.nih.gov/pubmed/28587102 http://dx.doi.org/10.3390/ijms18061138 |
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author | Blumenfeld, Britny Ben-Zimra, Micha Simon, Itamar |
author_facet | Blumenfeld, Britny Ben-Zimra, Micha Simon, Itamar |
author_sort | Blumenfeld, Britny |
collection | PubMed |
description | Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program. |
format | Online Article Text |
id | pubmed-5485962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54859622017-06-29 Perturbations in the Replication Program Contribute to Genomic Instability in Cancer Blumenfeld, Britny Ben-Zimra, Micha Simon, Itamar Int J Mol Sci Review Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program. MDPI 2017-05-25 /pmc/articles/PMC5485962/ /pubmed/28587102 http://dx.doi.org/10.3390/ijms18061138 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Blumenfeld, Britny Ben-Zimra, Micha Simon, Itamar Perturbations in the Replication Program Contribute to Genomic Instability in Cancer |
title | Perturbations in the Replication Program Contribute to Genomic Instability in Cancer |
title_full | Perturbations in the Replication Program Contribute to Genomic Instability in Cancer |
title_fullStr | Perturbations in the Replication Program Contribute to Genomic Instability in Cancer |
title_full_unstemmed | Perturbations in the Replication Program Contribute to Genomic Instability in Cancer |
title_short | Perturbations in the Replication Program Contribute to Genomic Instability in Cancer |
title_sort | perturbations in the replication program contribute to genomic instability in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485962/ https://www.ncbi.nlm.nih.gov/pubmed/28587102 http://dx.doi.org/10.3390/ijms18061138 |
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