Perturbations in the Replication Program Contribute to Genomic Instability in Cancer

Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or d...

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Detalles Bibliográficos
Autores principales: Blumenfeld, Britny, Ben-Zimra, Micha, Simon, Itamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485962/
https://www.ncbi.nlm.nih.gov/pubmed/28587102
http://dx.doi.org/10.3390/ijms18061138
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author Blumenfeld, Britny
Ben-Zimra, Micha
Simon, Itamar
author_facet Blumenfeld, Britny
Ben-Zimra, Micha
Simon, Itamar
author_sort Blumenfeld, Britny
collection PubMed
description Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.
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spelling pubmed-54859622017-06-29 Perturbations in the Replication Program Contribute to Genomic Instability in Cancer Blumenfeld, Britny Ben-Zimra, Micha Simon, Itamar Int J Mol Sci Review Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program. MDPI 2017-05-25 /pmc/articles/PMC5485962/ /pubmed/28587102 http://dx.doi.org/10.3390/ijms18061138 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Blumenfeld, Britny
Ben-Zimra, Micha
Simon, Itamar
Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
title Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
title_full Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
title_fullStr Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
title_full_unstemmed Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
title_short Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
title_sort perturbations in the replication program contribute to genomic instability in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485962/
https://www.ncbi.nlm.nih.gov/pubmed/28587102
http://dx.doi.org/10.3390/ijms18061138
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