The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma

Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tumors including hepatocellular carcinoma (HCC). Similar to previous reports, we have found the decrease in ASS expression in poorly differentiated HCC. These ASS(-) tumors are auxotrophic for arginine....

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Detalles Bibliográficos
Autores principales: Thongkum, Angkana, Wu, Chunjing, Li, Ying-Ying, Wangpaichitr, Medhi, Navasumrit, Panida, Parnlob, Varabhorn, Sricharunrat, Thaniya, Bhudhisawasdi, Vajarabhongsa, Ruchirawat, Mathuros, Savaraj, Niramol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485998/
https://www.ncbi.nlm.nih.gov/pubmed/28587170
http://dx.doi.org/10.3390/ijms18061175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485998/
https://www.ncbi.nlm.nih.gov/pubmed/28587170
http://dx.doi.org/10.3390/ijms18061175

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