Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration

Zebrafish are a popular vertebrate model in drug discovery. They produce a large number of small and rapidly-developing embryos. These embryos display rich visual-behaviors that can be used to screen drugs for treating retinal degeneration (RD). RD comprises blinding diseases such as Retinitis Pigme...

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Detalles Bibliográficos
Autores principales: Ganzen, Logan, Venkatraman, Prahatha, Pang, Chi Pui, Leung, Yuk Fai, Zhang, Mingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486008/
https://www.ncbi.nlm.nih.gov/pubmed/28574477
http://dx.doi.org/10.3390/ijms18061185
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author Ganzen, Logan
Venkatraman, Prahatha
Pang, Chi Pui
Leung, Yuk Fai
Zhang, Mingzhi
author_facet Ganzen, Logan
Venkatraman, Prahatha
Pang, Chi Pui
Leung, Yuk Fai
Zhang, Mingzhi
author_sort Ganzen, Logan
collection PubMed
description Zebrafish are a popular vertebrate model in drug discovery. They produce a large number of small and rapidly-developing embryos. These embryos display rich visual-behaviors that can be used to screen drugs for treating retinal degeneration (RD). RD comprises blinding diseases such as Retinitis Pigmentosa, which affects 1 in 4000 people. This disease has no definitive cure, emphasizing an urgency to identify new drugs. In this review, we will discuss advantages, challenges, and research developments in using zebrafish behaviors to screen drugs in vivo. We will specifically discuss a visual-motor response that can potentially expedite discovery of new RD drugs.
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spelling pubmed-54860082017-06-29 Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration Ganzen, Logan Venkatraman, Prahatha Pang, Chi Pui Leung, Yuk Fai Zhang, Mingzhi Int J Mol Sci Review Zebrafish are a popular vertebrate model in drug discovery. They produce a large number of small and rapidly-developing embryos. These embryos display rich visual-behaviors that can be used to screen drugs for treating retinal degeneration (RD). RD comprises blinding diseases such as Retinitis Pigmentosa, which affects 1 in 4000 people. This disease has no definitive cure, emphasizing an urgency to identify new drugs. In this review, we will discuss advantages, challenges, and research developments in using zebrafish behaviors to screen drugs in vivo. We will specifically discuss a visual-motor response that can potentially expedite discovery of new RD drugs. MDPI 2017-06-02 /pmc/articles/PMC5486008/ /pubmed/28574477 http://dx.doi.org/10.3390/ijms18061185 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ganzen, Logan
Venkatraman, Prahatha
Pang, Chi Pui
Leung, Yuk Fai
Zhang, Mingzhi
Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration
title Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration
title_full Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration
title_fullStr Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration
title_full_unstemmed Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration
title_short Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration
title_sort utilizing zebrafish visual behaviors in drug screening for retinal degeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486008/
https://www.ncbi.nlm.nih.gov/pubmed/28574477
http://dx.doi.org/10.3390/ijms18061185
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