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Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling

The binding of von Willebrand factor (VWF) to the platelet membrane glycoprotein 1b-IX (GP1b-IX) leads to activation of platelets. GP1b was shown to signal via the FcRγ-ITAM (Fc Receptor γ-Immunoreceptor tyrosine-based activation motif) pathway, activating spleen tyrosine kinase (Syk) and other tyro...

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Detalles Bibliográficos
Autores principales:	Badolia, Rachit, Kostyak, John C., Dangelmaier, Carol, Kunapuli, Satya P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486061/ https://www.ncbi.nlm.nih.gov/pubmed/28598382 http://dx.doi.org/10.3390/ijms18061238

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