Osteoblast Role in Rheumatic Diseases

Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activa...

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Detalles Bibliográficos
Autores principales: Corrado, Addolorata, Maruotti, Nicola, Cantatore, Francesco Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486094/
https://www.ncbi.nlm.nih.gov/pubmed/28617323
http://dx.doi.org/10.3390/ijms18061272
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author Corrado, Addolorata
Maruotti, Nicola
Cantatore, Francesco Paolo
author_facet Corrado, Addolorata
Maruotti, Nicola
Cantatore, Francesco Paolo
author_sort Corrado, Addolorata
collection PubMed
description Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) signaling, bone morphogenetic proteins (BMPs) pathway and other mechanisms have been described in osteoblasts. This review article is focused on current knowledge on the role of osteoblast dysregulation occurring in rheumatic diseases.
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spelling pubmed-54860942017-06-29 Osteoblast Role in Rheumatic Diseases Corrado, Addolorata Maruotti, Nicola Cantatore, Francesco Paolo Int J Mol Sci Review Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) signaling, bone morphogenetic proteins (BMPs) pathway and other mechanisms have been described in osteoblasts. This review article is focused on current knowledge on the role of osteoblast dysregulation occurring in rheumatic diseases. MDPI 2017-06-15 /pmc/articles/PMC5486094/ /pubmed/28617323 http://dx.doi.org/10.3390/ijms18061272 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Corrado, Addolorata
Maruotti, Nicola
Cantatore, Francesco Paolo
Osteoblast Role in Rheumatic Diseases
title Osteoblast Role in Rheumatic Diseases
title_full Osteoblast Role in Rheumatic Diseases
title_fullStr Osteoblast Role in Rheumatic Diseases
title_full_unstemmed Osteoblast Role in Rheumatic Diseases
title_short Osteoblast Role in Rheumatic Diseases
title_sort osteoblast role in rheumatic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486094/
https://www.ncbi.nlm.nih.gov/pubmed/28617323
http://dx.doi.org/10.3390/ijms18061272
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AT maruottinicola osteoblastroleinrheumaticdiseases
AT cantatorefrancescopaolo osteoblastroleinrheumaticdiseases

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