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Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in dise...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486099/ https://www.ncbi.nlm.nih.gov/pubmed/28617321 http://dx.doi.org/10.3390/ijms18061277 |
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author | Trend, Stephanie Jones, Anderson P. Geldenhuys, Sian Byrne, Scott N. Fabis-Pedrini, Marzena J. Nolan, David Booth, David R. Carroll, William M. Lucas, Robyn M. Kermode, Allan G. Hart, Prue H. |
author_facet | Trend, Stephanie Jones, Anderson P. Geldenhuys, Sian Byrne, Scott N. Fabis-Pedrini, Marzena J. Nolan, David Booth, David R. Carroll, William M. Lucas, Robyn M. Kermode, Allan G. Hart, Prue H. |
author_sort | Trend, Stephanie |
collection | PubMed |
description | It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI); n = 6) and late (≥27 days; n = 12) blood sampling. Transitional B cells were increased in the blood of CIS patients independently of when blood was taken. However, there were two time-dependent effects found in the late CIS group relative to HC, including decreased CD56bright NK cells, which correlated significantly with time since MRI, and increased CD141+ myeloid dendritic cell (mDC2) frequencies. Higher CD1c+ B cells and lower non-classical monocyte frequencies were characteristic of more recent demyelinating disease activity (ODC and early CIS). Analysing cell populations by time since symptoms (subjective) and diagnostic MRI (objective) may contribute to understanding CIS. |
format | Online Article Text |
id | pubmed-5486099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54860992017-06-29 Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI Trend, Stephanie Jones, Anderson P. Geldenhuys, Sian Byrne, Scott N. Fabis-Pedrini, Marzena J. Nolan, David Booth, David R. Carroll, William M. Lucas, Robyn M. Kermode, Allan G. Hart, Prue H. Int J Mol Sci Article It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI); n = 6) and late (≥27 days; n = 12) blood sampling. Transitional B cells were increased in the blood of CIS patients independently of when blood was taken. However, there were two time-dependent effects found in the late CIS group relative to HC, including decreased CD56bright NK cells, which correlated significantly with time since MRI, and increased CD141+ myeloid dendritic cell (mDC2) frequencies. Higher CD1c+ B cells and lower non-classical monocyte frequencies were characteristic of more recent demyelinating disease activity (ODC and early CIS). Analysing cell populations by time since symptoms (subjective) and diagnostic MRI (objective) may contribute to understanding CIS. MDPI 2017-06-15 /pmc/articles/PMC5486099/ /pubmed/28617321 http://dx.doi.org/10.3390/ijms18061277 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Trend, Stephanie Jones, Anderson P. Geldenhuys, Sian Byrne, Scott N. Fabis-Pedrini, Marzena J. Nolan, David Booth, David R. Carroll, William M. Lucas, Robyn M. Kermode, Allan G. Hart, Prue H. Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI |
title | Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI |
title_full | Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI |
title_fullStr | Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI |
title_full_unstemmed | Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI |
title_short | Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI |
title_sort | evolving identification of blood cells associated with clinically isolated syndrome: importance of time since clinical presentation and diagnostic mri |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486099/ https://www.ncbi.nlm.nih.gov/pubmed/28617321 http://dx.doi.org/10.3390/ijms18061277 |
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