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Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI

It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in dise...

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Autores principales: Trend, Stephanie, Jones, Anderson P., Geldenhuys, Sian, Byrne, Scott N., Fabis-Pedrini, Marzena J., Nolan, David, Booth, David R., Carroll, William M., Lucas, Robyn M., Kermode, Allan G., Hart, Prue H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486099/
https://www.ncbi.nlm.nih.gov/pubmed/28617321
http://dx.doi.org/10.3390/ijms18061277
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author Trend, Stephanie
Jones, Anderson P.
Geldenhuys, Sian
Byrne, Scott N.
Fabis-Pedrini, Marzena J.
Nolan, David
Booth, David R.
Carroll, William M.
Lucas, Robyn M.
Kermode, Allan G.
Hart, Prue H.
author_facet Trend, Stephanie
Jones, Anderson P.
Geldenhuys, Sian
Byrne, Scott N.
Fabis-Pedrini, Marzena J.
Nolan, David
Booth, David R.
Carroll, William M.
Lucas, Robyn M.
Kermode, Allan G.
Hart, Prue H.
author_sort Trend, Stephanie
collection PubMed
description It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI); n = 6) and late (≥27 days; n = 12) blood sampling. Transitional B cells were increased in the blood of CIS patients independently of when blood was taken. However, there were two time-dependent effects found in the late CIS group relative to HC, including decreased CD56bright NK cells, which correlated significantly with time since MRI, and increased CD141+ myeloid dendritic cell (mDC2) frequencies. Higher CD1c+ B cells and lower non-classical monocyte frequencies were characteristic of more recent demyelinating disease activity (ODC and early CIS). Analysing cell populations by time since symptoms (subjective) and diagnostic MRI (objective) may contribute to understanding CIS.
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spelling pubmed-54860992017-06-29 Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI Trend, Stephanie Jones, Anderson P. Geldenhuys, Sian Byrne, Scott N. Fabis-Pedrini, Marzena J. Nolan, David Booth, David R. Carroll, William M. Lucas, Robyn M. Kermode, Allan G. Hart, Prue H. Int J Mol Sci Article It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI); n = 6) and late (≥27 days; n = 12) blood sampling. Transitional B cells were increased in the blood of CIS patients independently of when blood was taken. However, there were two time-dependent effects found in the late CIS group relative to HC, including decreased CD56bright NK cells, which correlated significantly with time since MRI, and increased CD141+ myeloid dendritic cell (mDC2) frequencies. Higher CD1c+ B cells and lower non-classical monocyte frequencies were characteristic of more recent demyelinating disease activity (ODC and early CIS). Analysing cell populations by time since symptoms (subjective) and diagnostic MRI (objective) may contribute to understanding CIS. MDPI 2017-06-15 /pmc/articles/PMC5486099/ /pubmed/28617321 http://dx.doi.org/10.3390/ijms18061277 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trend, Stephanie
Jones, Anderson P.
Geldenhuys, Sian
Byrne, Scott N.
Fabis-Pedrini, Marzena J.
Nolan, David
Booth, David R.
Carroll, William M.
Lucas, Robyn M.
Kermode, Allan G.
Hart, Prue H.
Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
title Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
title_full Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
title_fullStr Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
title_full_unstemmed Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
title_short Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
title_sort evolving identification of blood cells associated with clinically isolated syndrome: importance of time since clinical presentation and diagnostic mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486099/
https://www.ncbi.nlm.nih.gov/pubmed/28617321
http://dx.doi.org/10.3390/ijms18061277
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