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Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying

Postprandial hypertriglyceridemia is a potential target for cardiovascular disease prevention in patients with diabetic dyslipidemia. Metformin has been reported to reduce plasma triglyceride concentrations in the postprandial states. However, little is known about the mechanisms underlying the trig...

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Autores principales: Sato, Daisuke, Morino, Katsutaro, Nakagawa, Fumiyuki, Murata, Koichiro, Sekine, Osamu, Beppu, Fumiaki, Gotoh, Naohiro, Ugi, Satoshi, Maegawa, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486104/
https://www.ncbi.nlm.nih.gov/pubmed/28621714
http://dx.doi.org/10.3390/ijms18061282
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author Sato, Daisuke
Morino, Katsutaro
Nakagawa, Fumiyuki
Murata, Koichiro
Sekine, Osamu
Beppu, Fumiaki
Gotoh, Naohiro
Ugi, Satoshi
Maegawa, Hiroshi
author_facet Sato, Daisuke
Morino, Katsutaro
Nakagawa, Fumiyuki
Murata, Koichiro
Sekine, Osamu
Beppu, Fumiaki
Gotoh, Naohiro
Ugi, Satoshi
Maegawa, Hiroshi
author_sort Sato, Daisuke
collection PubMed
description Postprandial hypertriglyceridemia is a potential target for cardiovascular disease prevention in patients with diabetic dyslipidemia. Metformin has been reported to reduce plasma triglyceride concentrations in the postprandial states. However, little is known about the mechanisms underlying the triglyceride-lowering effect of metformin. Here, we examined the effects of metformin on lipid metabolism after olive oil-loading in 129S mice fed a high fat diet for three weeks. Metformin administration (250 mg/kg) for one week decreased postprandial plasma triglycerides. Pre-administration (250 mg/kg) of metformin resulted in a stronger triglyceride-lowering effect (approximately 45% lower area under the curve) than post-administration. A single administration (250 mg/kg) of metformin lowered plasma postprandial triglycerides comparably to administration for one week, suggesting an acute effect of metformin on postprandial hypertriglyceridemia. To explore whole body lipid metabolism after fat-loading, stomach size, fat absorption in the intestine, and fat oxidation ((13)C/(12)C ratio in expired CO(2) after administration of glyceryl-1-(13)C tripalmitate) were measured with and without metformin (250 mg/kg) pre-treatment. In metformin-treated mice, larger stomach size, lower fat oxidation, and no change in lipid absorption were observed. In conclusion, metformin administration before fat loading reduced postprandial hypertriglyceridemia, most likely by delaying gastric emptying.
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spelling pubmed-54861042017-06-29 Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying Sato, Daisuke Morino, Katsutaro Nakagawa, Fumiyuki Murata, Koichiro Sekine, Osamu Beppu, Fumiaki Gotoh, Naohiro Ugi, Satoshi Maegawa, Hiroshi Int J Mol Sci Article Postprandial hypertriglyceridemia is a potential target for cardiovascular disease prevention in patients with diabetic dyslipidemia. Metformin has been reported to reduce plasma triglyceride concentrations in the postprandial states. However, little is known about the mechanisms underlying the triglyceride-lowering effect of metformin. Here, we examined the effects of metformin on lipid metabolism after olive oil-loading in 129S mice fed a high fat diet for three weeks. Metformin administration (250 mg/kg) for one week decreased postprandial plasma triglycerides. Pre-administration (250 mg/kg) of metformin resulted in a stronger triglyceride-lowering effect (approximately 45% lower area under the curve) than post-administration. A single administration (250 mg/kg) of metformin lowered plasma postprandial triglycerides comparably to administration for one week, suggesting an acute effect of metformin on postprandial hypertriglyceridemia. To explore whole body lipid metabolism after fat-loading, stomach size, fat absorption in the intestine, and fat oxidation ((13)C/(12)C ratio in expired CO(2) after administration of glyceryl-1-(13)C tripalmitate) were measured with and without metformin (250 mg/kg) pre-treatment. In metformin-treated mice, larger stomach size, lower fat oxidation, and no change in lipid absorption were observed. In conclusion, metformin administration before fat loading reduced postprandial hypertriglyceridemia, most likely by delaying gastric emptying. MDPI 2017-06-16 /pmc/articles/PMC5486104/ /pubmed/28621714 http://dx.doi.org/10.3390/ijms18061282 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sato, Daisuke
Morino, Katsutaro
Nakagawa, Fumiyuki
Murata, Koichiro
Sekine, Osamu
Beppu, Fumiaki
Gotoh, Naohiro
Ugi, Satoshi
Maegawa, Hiroshi
Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying
title Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying
title_full Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying
title_fullStr Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying
title_full_unstemmed Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying
title_short Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying
title_sort acute effect of metformin on postprandial hypertriglyceridemia through delayed gastric emptying
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486104/
https://www.ncbi.nlm.nih.gov/pubmed/28621714
http://dx.doi.org/10.3390/ijms18061282
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