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p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer

Ulcerative colitis (UC) is defined as an idiopathic inflammatory disorder primarily involving the mucosa and submucosa of the colon. UC-associated colon cancers (also known as colitic cancers) develop through the inflammation–dysplasia sequence, which is a major problem affecting the prognosis of pa...

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Autores principales: Kobayashi, Kazuhiro, Tomita, Hiroyuki, Shimizu, Masahito, Tanaka, Takuji, Suzui, Natsuko, Miyazaki, Tatsuhiko, Hara, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486106/
https://www.ncbi.nlm.nih.gov/pubmed/28621756
http://dx.doi.org/10.3390/ijms18061284
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author Kobayashi, Kazuhiro
Tomita, Hiroyuki
Shimizu, Masahito
Tanaka, Takuji
Suzui, Natsuko
Miyazaki, Tatsuhiko
Hara, Akira
author_facet Kobayashi, Kazuhiro
Tomita, Hiroyuki
Shimizu, Masahito
Tanaka, Takuji
Suzui, Natsuko
Miyazaki, Tatsuhiko
Hara, Akira
author_sort Kobayashi, Kazuhiro
collection PubMed
description Ulcerative colitis (UC) is defined as an idiopathic inflammatory disorder primarily involving the mucosa and submucosa of the colon. UC-associated colon cancers (also known as colitic cancers) develop through the inflammation–dysplasia sequence, which is a major problem affecting the prognosis of patients with UC. It is therefore very important to detect malignancy from UC at an early stage. As precancerous lesions arising in UC, there are pathological adenomatous changes, basal cell changes, in situ anaplasia, clear cell changes, and pan-cellular change. It is considered that the mutation of the p53 gene plays a crucial role, and the protein expression of p53 in dysplastic crypts may serve as a good biomarker in the early stages of UC-associated colon carcinogenesis. Immunohistochemistry for p53 is a very valuable diagnostic tool in UC-associated colon cancers. However, protein expression of p53 is not always universal, and additional methods may be required to assess p53 status in UC-associated colon cancers.
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spelling pubmed-54861062017-06-29 p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer Kobayashi, Kazuhiro Tomita, Hiroyuki Shimizu, Masahito Tanaka, Takuji Suzui, Natsuko Miyazaki, Tatsuhiko Hara, Akira Int J Mol Sci Review Ulcerative colitis (UC) is defined as an idiopathic inflammatory disorder primarily involving the mucosa and submucosa of the colon. UC-associated colon cancers (also known as colitic cancers) develop through the inflammation–dysplasia sequence, which is a major problem affecting the prognosis of patients with UC. It is therefore very important to detect malignancy from UC at an early stage. As precancerous lesions arising in UC, there are pathological adenomatous changes, basal cell changes, in situ anaplasia, clear cell changes, and pan-cellular change. It is considered that the mutation of the p53 gene plays a crucial role, and the protein expression of p53 in dysplastic crypts may serve as a good biomarker in the early stages of UC-associated colon carcinogenesis. Immunohistochemistry for p53 is a very valuable diagnostic tool in UC-associated colon cancers. However, protein expression of p53 is not always universal, and additional methods may be required to assess p53 status in UC-associated colon cancers. MDPI 2017-06-16 /pmc/articles/PMC5486106/ /pubmed/28621756 http://dx.doi.org/10.3390/ijms18061284 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kobayashi, Kazuhiro
Tomita, Hiroyuki
Shimizu, Masahito
Tanaka, Takuji
Suzui, Natsuko
Miyazaki, Tatsuhiko
Hara, Akira
p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer
title p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer
title_full p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer
title_fullStr p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer
title_full_unstemmed p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer
title_short p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer
title_sort p53 expression as a diagnostic biomarker in ulcerative colitis-associated cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486106/
https://www.ncbi.nlm.nih.gov/pubmed/28621756
http://dx.doi.org/10.3390/ijms18061284
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