Cargando…
The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology
Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A (TrkA) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (BFCN) associated with the progressive cognitive decline in Alzheimer's disease (AD)...
Autores principales: | Canu, Nadia, Amadoro, Giuseppina, Triaca, Viviana, Latina, Valentina, Sposato, Valentina, Corsetti, Veronica, Severini, Cinzia, Ciotti, Maria Teresa, Calissano, Pietro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486140/ https://www.ncbi.nlm.nih.gov/pubmed/28632177 http://dx.doi.org/10.3390/ijms18061319 |
Ejemplares similares
-
Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons
por: Latina, Valentina, et al.
Publicado: (2017) -
Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents
por: Canu, Nadia, et al.
Publicado: (2017) -
hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay
por: Triaca, Viviana, et al.
Publicado: (2020) -
NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model
por: Latina, Valentina, et al.
Publicado: (2018) -
NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease
por: Triaca, Viviana, et al.
Publicado: (2016)