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Fucaceae: A Source of Bioactive Phlorotannins

Fucaceae is the most dominant algae family along the intertidal areas of the Northern Hemisphere shorelines, being part of human customs for centuries with applications as a food source either for humans or animals, in agriculture and as remedies in folk medicine. These macroalgae are endowed with s...

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Detalles Bibliográficos
Autores principales: Catarino, Marcelo D., Silva, Artur M. S., Cardoso, Susana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486148/
https://www.ncbi.nlm.nih.gov/pubmed/28635652
http://dx.doi.org/10.3390/ijms18061327
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author Catarino, Marcelo D.
Silva, Artur M. S.
Cardoso, Susana M.
author_facet Catarino, Marcelo D.
Silva, Artur M. S.
Cardoso, Susana M.
author_sort Catarino, Marcelo D.
collection PubMed
description Fucaceae is the most dominant algae family along the intertidal areas of the Northern Hemisphere shorelines, being part of human customs for centuries with applications as a food source either for humans or animals, in agriculture and as remedies in folk medicine. These macroalgae are endowed with several phytochemicals of great industrial interest from which phlorotannins, a class of marine-exclusive polyphenols, have gathered much attention during the last few years due to their numerous possible therapeutic properties. These compounds are very abundant in brown seaweeds such as Fucaceae and have been demonstrated to possess numerous health-promoting properties, including antioxidant effects through scavenging of reactive oxygen species (ROS) or enhancement of intracellular antioxidant defenses, antidiabetic properties through their acarbose-like activity, stimulation of adipocytes glucose uptake and protection of β-pancreatic cells against high-glucose oxidative stress; anti-inflammatory effects through inhibition of several pro-inflammatory mediators; antitumor properties by activation of apoptosis on cancerous cells and metastasis inhibition, among others. These multiple health properties render phlorotannins great potential for application in numerous therapeutical approaches. This review addresses the major contribution of phlototannins for the biological effects that have been described for seaweeds from Fucaceae. In addition, the bioavailability of this group of phenolic compounds is discussed.
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spelling pubmed-54861482017-06-29 Fucaceae: A Source of Bioactive Phlorotannins Catarino, Marcelo D. Silva, Artur M. S. Cardoso, Susana M. Int J Mol Sci Review Fucaceae is the most dominant algae family along the intertidal areas of the Northern Hemisphere shorelines, being part of human customs for centuries with applications as a food source either for humans or animals, in agriculture and as remedies in folk medicine. These macroalgae are endowed with several phytochemicals of great industrial interest from which phlorotannins, a class of marine-exclusive polyphenols, have gathered much attention during the last few years due to their numerous possible therapeutic properties. These compounds are very abundant in brown seaweeds such as Fucaceae and have been demonstrated to possess numerous health-promoting properties, including antioxidant effects through scavenging of reactive oxygen species (ROS) or enhancement of intracellular antioxidant defenses, antidiabetic properties through their acarbose-like activity, stimulation of adipocytes glucose uptake and protection of β-pancreatic cells against high-glucose oxidative stress; anti-inflammatory effects through inhibition of several pro-inflammatory mediators; antitumor properties by activation of apoptosis on cancerous cells and metastasis inhibition, among others. These multiple health properties render phlorotannins great potential for application in numerous therapeutical approaches. This review addresses the major contribution of phlototannins for the biological effects that have been described for seaweeds from Fucaceae. In addition, the bioavailability of this group of phenolic compounds is discussed. MDPI 2017-06-21 /pmc/articles/PMC5486148/ /pubmed/28635652 http://dx.doi.org/10.3390/ijms18061327 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Catarino, Marcelo D.
Silva, Artur M. S.
Cardoso, Susana M.
Fucaceae: A Source of Bioactive Phlorotannins
title Fucaceae: A Source of Bioactive Phlorotannins
title_full Fucaceae: A Source of Bioactive Phlorotannins
title_fullStr Fucaceae: A Source of Bioactive Phlorotannins
title_full_unstemmed Fucaceae: A Source of Bioactive Phlorotannins
title_short Fucaceae: A Source of Bioactive Phlorotannins
title_sort fucaceae: a source of bioactive phlorotannins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486148/
https://www.ncbi.nlm.nih.gov/pubmed/28635652
http://dx.doi.org/10.3390/ijms18061327
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