MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma

Neuroblastoma (NB) is the most common extracranial solid tumor occurring in childhood. Amplification of the MYCN oncogene is associated with poor prognosis. Downregulation on NB cells of ligands recognized by Natural Killer (NK) cell-activating receptors, involved in tumor cell recognition and lysis...

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Detalles Bibliográficos
Autores principales: Brandetti, Elisa, Veneziani, Irene, Melaiu, Ombretta, Pezzolo, Annalisa, Castellano, Aurora, Boldrini, Renata, Ferretti, Elisa, Fruci, Doriana, Moretta, Lorenzo, Pistoia, Vito, Locatelli, Franco, Cifaldi, Loredana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486189/
https://www.ncbi.nlm.nih.gov/pubmed/28680748
http://dx.doi.org/10.1080/2162402X.2017.1316439

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