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The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity
We investigated the association between dietary intake of n-3 and n-6 polyunsaturated fatty acids (PUFAs), serum profiles, and immune and inflammatory markers in juvenile idiopathic arthritis (JIA) in relation to onset, activity, and duration. A total of 66 JIA patients and 42 controls were included...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer London
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486496/ https://www.ncbi.nlm.nih.gov/pubmed/28247163 http://dx.doi.org/10.1007/s10067-017-3586-9 |
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author | Gorczyca, Daiva Postępski, Jacek Czajkowska, Aleksandra Paściak, Mariola Prescha, Anna Olesińska, Edyta Gruenpeter, Anna Lachór-Motyka, Iwona Szponar, Bogumiła |
author_facet | Gorczyca, Daiva Postępski, Jacek Czajkowska, Aleksandra Paściak, Mariola Prescha, Anna Olesińska, Edyta Gruenpeter, Anna Lachór-Motyka, Iwona Szponar, Bogumiła |
author_sort | Gorczyca, Daiva |
collection | PubMed |
description | We investigated the association between dietary intake of n-3 and n-6 polyunsaturated fatty acids (PUFAs), serum profiles, and immune and inflammatory markers in juvenile idiopathic arthritis (JIA) in relation to onset, activity, and duration. A total of 66 JIA patients and 42 controls were included. Serum PUFA levels were assessed by gas-liquid chromatography-mass spectrometry, a dietary intake by 7-day dietary record method, and IL-6, IL-10, and IL-17A levels using ELISA. Dietary PUFA intake did not differ between the JIA group and controls. Intakes of n-6 and n-3 PUFA and serum levels were not associated. Levels of total n-6 PUFA and linoleic acid (LA) were higher in inactive JIA than in active JIA. Patients with active and short-lasting disease (less than 3 months from diagnosis) had significantly lower levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) than the control. Serum α-linolenic acid (ALA) levels were significantly higher in poly-JIA than in oligo-JIA and in controls. We found significantly higher serum IL-10 levels in JIA than in controls. Serum n-6 and n-3 levels were significantly negatively correlated with active joint count, erythrocyte sedimentation rate, and C-reactive protein and positively with platelet count. Our study presents the low levels of AA and DHA in the active phase of short-lasting JIA, particularly poly-JIA, and the relationship between n-6 and n-3 PUFA and classic markers of inflammation. PUFAs may contribute to the pathogenesis of JIA and support a necessity to identify new targets suitable for successful interventional studies in JIA patients. |
format | Online Article Text |
id | pubmed-5486496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer London |
record_format | MEDLINE/PubMed |
spelling | pubmed-54864962017-07-17 The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity Gorczyca, Daiva Postępski, Jacek Czajkowska, Aleksandra Paściak, Mariola Prescha, Anna Olesińska, Edyta Gruenpeter, Anna Lachór-Motyka, Iwona Szponar, Bogumiła Clin Rheumatol Original Article We investigated the association between dietary intake of n-3 and n-6 polyunsaturated fatty acids (PUFAs), serum profiles, and immune and inflammatory markers in juvenile idiopathic arthritis (JIA) in relation to onset, activity, and duration. A total of 66 JIA patients and 42 controls were included. Serum PUFA levels were assessed by gas-liquid chromatography-mass spectrometry, a dietary intake by 7-day dietary record method, and IL-6, IL-10, and IL-17A levels using ELISA. Dietary PUFA intake did not differ between the JIA group and controls. Intakes of n-6 and n-3 PUFA and serum levels were not associated. Levels of total n-6 PUFA and linoleic acid (LA) were higher in inactive JIA than in active JIA. Patients with active and short-lasting disease (less than 3 months from diagnosis) had significantly lower levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) than the control. Serum α-linolenic acid (ALA) levels were significantly higher in poly-JIA than in oligo-JIA and in controls. We found significantly higher serum IL-10 levels in JIA than in controls. Serum n-6 and n-3 levels were significantly negatively correlated with active joint count, erythrocyte sedimentation rate, and C-reactive protein and positively with platelet count. Our study presents the low levels of AA and DHA in the active phase of short-lasting JIA, particularly poly-JIA, and the relationship between n-6 and n-3 PUFA and classic markers of inflammation. PUFAs may contribute to the pathogenesis of JIA and support a necessity to identify new targets suitable for successful interventional studies in JIA patients. Springer London 2017-02-28 2017 /pmc/articles/PMC5486496/ /pubmed/28247163 http://dx.doi.org/10.1007/s10067-017-3586-9 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Gorczyca, Daiva Postępski, Jacek Czajkowska, Aleksandra Paściak, Mariola Prescha, Anna Olesińska, Edyta Gruenpeter, Anna Lachór-Motyka, Iwona Szponar, Bogumiła The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity |
title | The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity |
title_full | The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity |
title_fullStr | The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity |
title_full_unstemmed | The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity |
title_short | The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity |
title_sort | profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486496/ https://www.ncbi.nlm.nih.gov/pubmed/28247163 http://dx.doi.org/10.1007/s10067-017-3586-9 |
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