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Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer

PURPOSE: Resistance to trastuzumab therapy is linked to phosphoinositol 3-kinase (PI3K) pathway activation. One key downstream effector and regulator of this pathway is the mechanistic target of rapamycin (mTOR). In 2011, a phase I/II study evaluated the combination of trastuzumab and everolimus (a...

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Detalles Bibliográficos
Autores principales:	de Oliveira Taveira, Mateus, Nabavi, Sheida, Wang, Yuker, Tonellato, Peter, Esteva, Francisco J., Cantley, Lewis C., Wulf, Gerburg M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Original Article – Clinical Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486569/ https://www.ncbi.nlm.nih.gov/pubmed/28247034 http://dx.doi.org/10.1007/s00432-017-2358-x

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