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The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats

Lithium is widely used in medicine and the therapy is often long term. Apart from beneficial effects, its application can cause diverse side effects. The current study was performed with the aim of the evaluation of the effect of lithium and/or selenium administration on magnesium, calcium and silic...

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Autores principales: Kiełczykowska, Małgorzata, Musik, Irena, Kurzepa, Jacek, Żelazowska, Renata, Lewandowska, Anna, Paździor, Marek, Kocot, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486587/
https://www.ncbi.nlm.nih.gov/pubmed/27957665
http://dx.doi.org/10.1007/s12011-016-0906-x
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author Kiełczykowska, Małgorzata
Musik, Irena
Kurzepa, Jacek
Żelazowska, Renata
Lewandowska, Anna
Paździor, Marek
Kocot, Joanna
author_facet Kiełczykowska, Małgorzata
Musik, Irena
Kurzepa, Jacek
Żelazowska, Renata
Lewandowska, Anna
Paździor, Marek
Kocot, Joanna
author_sort Kiełczykowska, Małgorzata
collection PubMed
description Lithium is widely used in medicine and the therapy is often long term. Apart from beneficial effects, its application can cause diverse side effects. The current study was performed with the aim of the evaluation of the effect of lithium and/or selenium administration on magnesium, calcium and silicon levels in rats. The study was performed on rats divided into four groups (six animals each): control—received saline, Li—received Li(2)CO(3) (2.7 mg Li/kg b.w.), Se—received Na(2)SeO(3)·H(2)O (0.5 mg Se/kg b.w.), and Li+Se—received simultaneously Li(2)CO(3) and Na(2)SeO(3)·H(2)O (2.7 and 0.5 mg Se/kg b.w.). The administration was performed in form of water solutions by a stomach tube once a day for 6 weeks. In the organs (liver, kidney, brain, spleen, heart, lung and femoral muscle), the concentrations of magnesium, calcium and silicon were determined. Lithium significantly increased Ca in the kidney, brain and spleen. Coadministration of selenium reversed this effect. No changes of magnesium in organs were observed. Silicon was affected only in spleen—an increase vs. control was observed in all studied groups. The beneficial influence of coadministration of selenium in case of calcium lets us suggest that an issue of its possible use as an adjuvant alleviating side effects in lithium-treated subjects is worth being continued.
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spelling pubmed-54865872017-07-11 The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats Kiełczykowska, Małgorzata Musik, Irena Kurzepa, Jacek Żelazowska, Renata Lewandowska, Anna Paździor, Marek Kocot, Joanna Biol Trace Elem Res Article Lithium is widely used in medicine and the therapy is often long term. Apart from beneficial effects, its application can cause diverse side effects. The current study was performed with the aim of the evaluation of the effect of lithium and/or selenium administration on magnesium, calcium and silicon levels in rats. The study was performed on rats divided into four groups (six animals each): control—received saline, Li—received Li(2)CO(3) (2.7 mg Li/kg b.w.), Se—received Na(2)SeO(3)·H(2)O (0.5 mg Se/kg b.w.), and Li+Se—received simultaneously Li(2)CO(3) and Na(2)SeO(3)·H(2)O (2.7 and 0.5 mg Se/kg b.w.). The administration was performed in form of water solutions by a stomach tube once a day for 6 weeks. In the organs (liver, kidney, brain, spleen, heart, lung and femoral muscle), the concentrations of magnesium, calcium and silicon were determined. Lithium significantly increased Ca in the kidney, brain and spleen. Coadministration of selenium reversed this effect. No changes of magnesium in organs were observed. Silicon was affected only in spleen—an increase vs. control was observed in all studied groups. The beneficial influence of coadministration of selenium in case of calcium lets us suggest that an issue of its possible use as an adjuvant alleviating side effects in lithium-treated subjects is worth being continued. Springer US 2016-12-12 2017 /pmc/articles/PMC5486587/ /pubmed/27957665 http://dx.doi.org/10.1007/s12011-016-0906-x Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Kiełczykowska, Małgorzata
Musik, Irena
Kurzepa, Jacek
Żelazowska, Renata
Lewandowska, Anna
Paździor, Marek
Kocot, Joanna
The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats
title The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats
title_full The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats
title_fullStr The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats
title_full_unstemmed The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats
title_short The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats
title_sort influence of lithium and/or selenium treatment on homeostasis of chosen bioelements in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486587/
https://www.ncbi.nlm.nih.gov/pubmed/27957665
http://dx.doi.org/10.1007/s12011-016-0906-x
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