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Genetics of Depression: Progress at Last

PURPOSE OF REVIEW: We will describe the success of recent genome-wide association studies that identify genetic variants associated with depression and outline the strategies used to reduce heterogeneity and increase sample size. RECENT FINDINGS: The CONVERGE consortium identified two genetic associ...

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Autores principales: Mullins, Niamh, Lewis, Cathryn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486596/
https://www.ncbi.nlm.nih.gov/pubmed/28608123
http://dx.doi.org/10.1007/s11920-017-0803-9
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author Mullins, Niamh
Lewis, Cathryn M.
author_facet Mullins, Niamh
Lewis, Cathryn M.
author_sort Mullins, Niamh
collection PubMed
description PURPOSE OF REVIEW: We will describe the success of recent genome-wide association studies that identify genetic variants associated with depression and outline the strategies used to reduce heterogeneity and increase sample size. RECENT FINDINGS: The CONVERGE consortium identified two genetic associations by focusing on a sample of Chinese women with recurrent severe depression. Three other loci have been found in Europeans by combining cohorts with clinical diagnosis and measures of depressive symptoms to increase sample size. 23andMe identified 15 loci associated with depression using self-report of clinical diagnosis in a study of over 300,000 individuals. SUMMARY: The first genetic associations with depression have been identified, and this number is now expected to increase linearly with sample size, as seen in other polygenic disorders. These loci provide invaluable insights into the biology of depression and exciting opportunities to develop new biomarkers and therapeutic targets.
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spelling pubmed-54865962017-07-11 Genetics of Depression: Progress at Last Mullins, Niamh Lewis, Cathryn M. Curr Psychiatry Rep Genetic Disorders (F Goes, Section Editor) PURPOSE OF REVIEW: We will describe the success of recent genome-wide association studies that identify genetic variants associated with depression and outline the strategies used to reduce heterogeneity and increase sample size. RECENT FINDINGS: The CONVERGE consortium identified two genetic associations by focusing on a sample of Chinese women with recurrent severe depression. Three other loci have been found in Europeans by combining cohorts with clinical diagnosis and measures of depressive symptoms to increase sample size. 23andMe identified 15 loci associated with depression using self-report of clinical diagnosis in a study of over 300,000 individuals. SUMMARY: The first genetic associations with depression have been identified, and this number is now expected to increase linearly with sample size, as seen in other polygenic disorders. These loci provide invaluable insights into the biology of depression and exciting opportunities to develop new biomarkers and therapeutic targets. Springer US 2017-06-13 2017 /pmc/articles/PMC5486596/ /pubmed/28608123 http://dx.doi.org/10.1007/s11920-017-0803-9 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Genetic Disorders (F Goes, Section Editor)
Mullins, Niamh
Lewis, Cathryn M.
Genetics of Depression: Progress at Last
title Genetics of Depression: Progress at Last
title_full Genetics of Depression: Progress at Last
title_fullStr Genetics of Depression: Progress at Last
title_full_unstemmed Genetics of Depression: Progress at Last
title_short Genetics of Depression: Progress at Last
title_sort genetics of depression: progress at last
topic Genetic Disorders (F Goes, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486596/
https://www.ncbi.nlm.nih.gov/pubmed/28608123
http://dx.doi.org/10.1007/s11920-017-0803-9
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