25I-NBOH: a new potent serotonin 5-HT(2A) receptor agonist identified in blotter paper seizures in Brazil

A new potent serotonin 5-HT(2A) receptor agonist was identified in blotter papers by several state level forensic laboratories in Brazil. The 25I-NBOH is a labile molecule, which fragments into 2C-I when analyzed by routine seized material screening gas chromatography (GC) methods. GC–mass spectrome...

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Detalles Bibliográficos
Autores principales: Arantes, Luciano Chaves, Júnior, Ettore Ferrari, de Souza, Luciano Figueiredo, Cardoso, Andriele Costa, Alcântara, Thaynara Lino Fernandes, Lião, Luciano Morais, Machado, Yuri, Lordeiro, Rogério Araújo, Neto, José Coelho, Andrade, Ana Flávia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486617/
https://www.ncbi.nlm.nih.gov/pubmed/28706567
http://dx.doi.org/10.1007/s11419-017-0357-x
Descripción
Sumario:A new potent serotonin 5-HT(2A) receptor agonist was identified in blotter papers by several state level forensic laboratories in Brazil. The 25I-NBOH is a labile molecule, which fragments into 2C-I when analyzed by routine seized material screening gas chromatography (GC) methods. GC–mass spectrometry (MS), liquid chromatography–quadrupole time-of-flight-MS, and Fourier transform infrared and nuclear magnetic resonance analyses were performed to complete molecular characterization. Individual doses range from 300 to 1000 μg. Despite its being a potent 5-HT(2A) receptor agonist, 25I-NBOH is neither registered in the United Nations Office on Drugs and Crime (UNODC) nor classified as a scheduled substance in most countries. Sweden and Brazil seem to be the only countries to control 25I-NBOH. To our knowledge, this is the first scientific report dealing with identification of 25I-NBOH in actual seizures.

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