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The relationship between the dopaminergic system and depressive symptoms in cervical dystonia

PURPOSE: Cervical dystonia (CD) is associated with tremor/jerks (50%) and psychiatric complaints (17–70%). The dopaminergic system has been implicated in the pathophysiology of CD in animal and imaging studies. Dopamine may be related to the motor as well as non-motor symptoms of CD. CD is associate...

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Autores principales: Zoons, E., Tijssen, M. A. J., Dreissen, Y. E. M., Speelman, J. D., Smit, M., Booij, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486819/
https://www.ncbi.nlm.nih.gov/pubmed/28314910
http://dx.doi.org/10.1007/s00259-017-3664-x
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author Zoons, E.
Tijssen, M. A. J.
Dreissen, Y. E. M.
Speelman, J. D.
Smit, M.
Booij, J.
author_facet Zoons, E.
Tijssen, M. A. J.
Dreissen, Y. E. M.
Speelman, J. D.
Smit, M.
Booij, J.
author_sort Zoons, E.
collection PubMed
description PURPOSE: Cervical dystonia (CD) is associated with tremor/jerks (50%) and psychiatric complaints (17–70%). The dopaminergic system has been implicated in the pathophysiology of CD in animal and imaging studies. Dopamine may be related to the motor as well as non-motor symptoms of CD. CD is associated with reduced striatal dopamine D(2/3) (D2/3) receptor and increased dopamine transporter (DAT) binding. There are differences in the dopamine system between CD patients with and without jerks/tremor and psychiatric symptoms. METHODS: Patients with CD and healthy controls underwent neurological and psychiatric examinations. Striatal DAT and D2/3 receptor binding were assessed using [(123)I]FP-CIT and [(123)I]IBZM SPECT, respectively. The ratio of specific striatal to non-specific binding (binding potential; BP(ND)) was the outcome measure. RESULTS: Twenty-seven patients with CD and 15 matched controls were included. Nineteen percent of patients fulfilled the criteria for a depression. Striatal DAT BP(ND) was significantly lower in depressed versus non-depressed CD patients. Higher DAT BP(ND) correlated significantly with higher scores on the Unified Myoclonus Rating Scale (UMRS). The striatal D2/3 receptor BP(ND) in CD patients showed a trend towards lower binding compared to controls. The D2/3 BP(ND) was significantly lower in depressed versus non-depressed CD patients. A significant correlation between DAT and D2/3R BP(ND) was found in both in patients and controls. CONCLUSIONS: Alterations of striatal DAT and D2/3 receptor binding in CD patients are related mainly to depression. DAT BP(ND) correlates significantly with scores on the UMRS, suggesting a role for dopamine in the pathophysiology of tremor/jerks in CD.
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spelling pubmed-54868192017-07-11 The relationship between the dopaminergic system and depressive symptoms in cervical dystonia Zoons, E. Tijssen, M. A. J. Dreissen, Y. E. M. Speelman, J. D. Smit, M. Booij, J. Eur J Nucl Med Mol Imaging Original Article PURPOSE: Cervical dystonia (CD) is associated with tremor/jerks (50%) and psychiatric complaints (17–70%). The dopaminergic system has been implicated in the pathophysiology of CD in animal and imaging studies. Dopamine may be related to the motor as well as non-motor symptoms of CD. CD is associated with reduced striatal dopamine D(2/3) (D2/3) receptor and increased dopamine transporter (DAT) binding. There are differences in the dopamine system between CD patients with and without jerks/tremor and psychiatric symptoms. METHODS: Patients with CD and healthy controls underwent neurological and psychiatric examinations. Striatal DAT and D2/3 receptor binding were assessed using [(123)I]FP-CIT and [(123)I]IBZM SPECT, respectively. The ratio of specific striatal to non-specific binding (binding potential; BP(ND)) was the outcome measure. RESULTS: Twenty-seven patients with CD and 15 matched controls were included. Nineteen percent of patients fulfilled the criteria for a depression. Striatal DAT BP(ND) was significantly lower in depressed versus non-depressed CD patients. Higher DAT BP(ND) correlated significantly with higher scores on the Unified Myoclonus Rating Scale (UMRS). The striatal D2/3 receptor BP(ND) in CD patients showed a trend towards lower binding compared to controls. The D2/3 BP(ND) was significantly lower in depressed versus non-depressed CD patients. A significant correlation between DAT and D2/3R BP(ND) was found in both in patients and controls. CONCLUSIONS: Alterations of striatal DAT and D2/3 receptor binding in CD patients are related mainly to depression. DAT BP(ND) correlates significantly with scores on the UMRS, suggesting a role for dopamine in the pathophysiology of tremor/jerks in CD. Springer Berlin Heidelberg 2017-03-17 2017 /pmc/articles/PMC5486819/ /pubmed/28314910 http://dx.doi.org/10.1007/s00259-017-3664-x Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Zoons, E.
Tijssen, M. A. J.
Dreissen, Y. E. M.
Speelman, J. D.
Smit, M.
Booij, J.
The relationship between the dopaminergic system and depressive symptoms in cervical dystonia
title The relationship between the dopaminergic system and depressive symptoms in cervical dystonia
title_full The relationship between the dopaminergic system and depressive symptoms in cervical dystonia
title_fullStr The relationship between the dopaminergic system and depressive symptoms in cervical dystonia
title_full_unstemmed The relationship between the dopaminergic system and depressive symptoms in cervical dystonia
title_short The relationship between the dopaminergic system and depressive symptoms in cervical dystonia
title_sort relationship between the dopaminergic system and depressive symptoms in cervical dystonia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486819/
https://www.ncbi.nlm.nih.gov/pubmed/28314910
http://dx.doi.org/10.1007/s00259-017-3664-x
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