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Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life

PURPOSE: Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term healt...

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Autores principales: van Roekel, Eline H., Bours, Martijn J. L., te Molder, Malou E. M., Breedveld-Peters, José J. L., Olde Damink, Steven W. M., Schouten, Leo J., Sanduleanu, Silvia, Beets, Geerard L., Weijenberg, Matty P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486890/
https://www.ncbi.nlm.nih.gov/pubmed/28315175
http://dx.doi.org/10.1007/s11136-017-1539-z
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author van Roekel, Eline H.
Bours, Martijn J. L.
te Molder, Malou E. M.
Breedveld-Peters, José J. L.
Olde Damink, Steven W. M.
Schouten, Leo J.
Sanduleanu, Silvia
Beets, Geerard L.
Weijenberg, Matty P.
author_facet van Roekel, Eline H.
Bours, Martijn J. L.
te Molder, Malou E. M.
Breedveld-Peters, José J. L.
Olde Damink, Steven W. M.
Schouten, Leo J.
Sanduleanu, Silvia
Beets, Geerard L.
Weijenberg, Matty P.
author_sort van Roekel, Eline H.
collection PubMed
description PURPOSE: Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life (HRQoL) have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2–10 years post-diagnosis. METHODS: A cross-sectional study was conducted in 104 stage I‒III CRC survivors, diagnosed at Maastricht University Medical Center+, the Netherlands (2002–2010). Diagnostic CT images at the level of the third lumbar vertebra were analyzed to retrospectively determine visceral adipose tissue area (cm(2)); intermuscular adipose tissue area (cm(2)) and mean muscle attenuation (Hounsfield units) as measures of muscle fat infiltration; and skeletal muscle index (SMI, cm(2)/m(2)) as measure of muscle mass and for determining sarcopenia. RESULTS: Participants showed a large variation in body composition parameters at CRC diagnosis with a mean visceral adipose tissue area of 136.1 cm(2) (standard deviation: 93.4) and SMI of 47.8 cm(2)/m(2) (7.2); 47% was classified as being viscerally obese, and 32% as sarcopenic. In multivariable linear regression models, associations of the body composition parameters with long-term global quality of life, physical, role and social functioning, disability, fatigue, and distress were not significant, and observed mean differences were below predefined minimal important differences. CONCLUSIONS: Although visceral obesity and sarcopenia are relatively common at CRC diagnosis, we found no significant associations of these parameters with long-term HRQoL in stage I–III CRC survivors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11136-017-1539-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-54868902017-07-17 Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life van Roekel, Eline H. Bours, Martijn J. L. te Molder, Malou E. M. Breedveld-Peters, José J. L. Olde Damink, Steven W. M. Schouten, Leo J. Sanduleanu, Silvia Beets, Geerard L. Weijenberg, Matty P. Qual Life Res Article PURPOSE: Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life (HRQoL) have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2–10 years post-diagnosis. METHODS: A cross-sectional study was conducted in 104 stage I‒III CRC survivors, diagnosed at Maastricht University Medical Center+, the Netherlands (2002–2010). Diagnostic CT images at the level of the third lumbar vertebra were analyzed to retrospectively determine visceral adipose tissue area (cm(2)); intermuscular adipose tissue area (cm(2)) and mean muscle attenuation (Hounsfield units) as measures of muscle fat infiltration; and skeletal muscle index (SMI, cm(2)/m(2)) as measure of muscle mass and for determining sarcopenia. RESULTS: Participants showed a large variation in body composition parameters at CRC diagnosis with a mean visceral adipose tissue area of 136.1 cm(2) (standard deviation: 93.4) and SMI of 47.8 cm(2)/m(2) (7.2); 47% was classified as being viscerally obese, and 32% as sarcopenic. In multivariable linear regression models, associations of the body composition parameters with long-term global quality of life, physical, role and social functioning, disability, fatigue, and distress were not significant, and observed mean differences were below predefined minimal important differences. CONCLUSIONS: Although visceral obesity and sarcopenia are relatively common at CRC diagnosis, we found no significant associations of these parameters with long-term HRQoL in stage I–III CRC survivors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11136-017-1539-z) contains supplementary material, which is available to authorized users. Springer International Publishing 2017-03-17 2017 /pmc/articles/PMC5486890/ /pubmed/28315175 http://dx.doi.org/10.1007/s11136-017-1539-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
van Roekel, Eline H.
Bours, Martijn J. L.
te Molder, Malou E. M.
Breedveld-Peters, José J. L.
Olde Damink, Steven W. M.
Schouten, Leo J.
Sanduleanu, Silvia
Beets, Geerard L.
Weijenberg, Matty P.
Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
title Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
title_full Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
title_fullStr Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
title_full_unstemmed Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
title_short Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
title_sort associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486890/
https://www.ncbi.nlm.nih.gov/pubmed/28315175
http://dx.doi.org/10.1007/s11136-017-1539-z
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