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Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
PURPOSE: Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term healt...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486890/ https://www.ncbi.nlm.nih.gov/pubmed/28315175 http://dx.doi.org/10.1007/s11136-017-1539-z |
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author | van Roekel, Eline H. Bours, Martijn J. L. te Molder, Malou E. M. Breedveld-Peters, José J. L. Olde Damink, Steven W. M. Schouten, Leo J. Sanduleanu, Silvia Beets, Geerard L. Weijenberg, Matty P. |
author_facet | van Roekel, Eline H. Bours, Martijn J. L. te Molder, Malou E. M. Breedveld-Peters, José J. L. Olde Damink, Steven W. M. Schouten, Leo J. Sanduleanu, Silvia Beets, Geerard L. Weijenberg, Matty P. |
author_sort | van Roekel, Eline H. |
collection | PubMed |
description | PURPOSE: Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life (HRQoL) have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2–10 years post-diagnosis. METHODS: A cross-sectional study was conducted in 104 stage I‒III CRC survivors, diagnosed at Maastricht University Medical Center+, the Netherlands (2002–2010). Diagnostic CT images at the level of the third lumbar vertebra were analyzed to retrospectively determine visceral adipose tissue area (cm(2)); intermuscular adipose tissue area (cm(2)) and mean muscle attenuation (Hounsfield units) as measures of muscle fat infiltration; and skeletal muscle index (SMI, cm(2)/m(2)) as measure of muscle mass and for determining sarcopenia. RESULTS: Participants showed a large variation in body composition parameters at CRC diagnosis with a mean visceral adipose tissue area of 136.1 cm(2) (standard deviation: 93.4) and SMI of 47.8 cm(2)/m(2) (7.2); 47% was classified as being viscerally obese, and 32% as sarcopenic. In multivariable linear regression models, associations of the body composition parameters with long-term global quality of life, physical, role and social functioning, disability, fatigue, and distress were not significant, and observed mean differences were below predefined minimal important differences. CONCLUSIONS: Although visceral obesity and sarcopenia are relatively common at CRC diagnosis, we found no significant associations of these parameters with long-term HRQoL in stage I–III CRC survivors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11136-017-1539-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5486890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-54868902017-07-17 Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life van Roekel, Eline H. Bours, Martijn J. L. te Molder, Malou E. M. Breedveld-Peters, José J. L. Olde Damink, Steven W. M. Schouten, Leo J. Sanduleanu, Silvia Beets, Geerard L. Weijenberg, Matty P. Qual Life Res Article PURPOSE: Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life (HRQoL) have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2–10 years post-diagnosis. METHODS: A cross-sectional study was conducted in 104 stage I‒III CRC survivors, diagnosed at Maastricht University Medical Center+, the Netherlands (2002–2010). Diagnostic CT images at the level of the third lumbar vertebra were analyzed to retrospectively determine visceral adipose tissue area (cm(2)); intermuscular adipose tissue area (cm(2)) and mean muscle attenuation (Hounsfield units) as measures of muscle fat infiltration; and skeletal muscle index (SMI, cm(2)/m(2)) as measure of muscle mass and for determining sarcopenia. RESULTS: Participants showed a large variation in body composition parameters at CRC diagnosis with a mean visceral adipose tissue area of 136.1 cm(2) (standard deviation: 93.4) and SMI of 47.8 cm(2)/m(2) (7.2); 47% was classified as being viscerally obese, and 32% as sarcopenic. In multivariable linear regression models, associations of the body composition parameters with long-term global quality of life, physical, role and social functioning, disability, fatigue, and distress were not significant, and observed mean differences were below predefined minimal important differences. CONCLUSIONS: Although visceral obesity and sarcopenia are relatively common at CRC diagnosis, we found no significant associations of these parameters with long-term HRQoL in stage I–III CRC survivors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11136-017-1539-z) contains supplementary material, which is available to authorized users. Springer International Publishing 2017-03-17 2017 /pmc/articles/PMC5486890/ /pubmed/28315175 http://dx.doi.org/10.1007/s11136-017-1539-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article van Roekel, Eline H. Bours, Martijn J. L. te Molder, Malou E. M. Breedveld-Peters, José J. L. Olde Damink, Steven W. M. Schouten, Leo J. Sanduleanu, Silvia Beets, Geerard L. Weijenberg, Matty P. Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life |
title | Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life |
title_full | Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life |
title_fullStr | Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life |
title_full_unstemmed | Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life |
title_short | Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life |
title_sort | associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486890/ https://www.ncbi.nlm.nih.gov/pubmed/28315175 http://dx.doi.org/10.1007/s11136-017-1539-z |
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