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Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study
BACKGROUND: Polarising currents can modulate membrane potentials in animals, affecting the after-effect of theta burst stimulation (TBS) on synaptic strength. OBJECTIVE: We examined whether a similar phenomenon could also be observed in human motor cortex (M1) using transcranial direct current stimu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487022/ https://www.ncbi.nlm.nih.gov/pubmed/28404455 http://dx.doi.org/10.1016/j.brs.2017.03.009 |
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author | Tremblay, Sara Hannah, Ricci Rawji, Vishal Rothwell, John C. |
author_facet | Tremblay, Sara Hannah, Ricci Rawji, Vishal Rothwell, John C. |
author_sort | Tremblay, Sara |
collection | PubMed |
description | BACKGROUND: Polarising currents can modulate membrane potentials in animals, affecting the after-effect of theta burst stimulation (TBS) on synaptic strength. OBJECTIVE: We examined whether a similar phenomenon could also be observed in human motor cortex (M1) using transcranial direct current stimulation (TDCS) during monophasic intermittent TBS (iTBS). METHODS: TDCS was applied during posterior-anterior iTBS using three different conditions: posterior-anterior TDCS (anode 3.5 cm posterior to M1, cathode 3.5 cm anterior to M1), anterior-posterior TDCS (cathode 3.5 cm posterior to M1, anode 3.5 cm anterior to M1), and sham TDCS. RESULTS: When the direction of TDCS (posterior-anterior) matched the direction of the electrical field induced by iTBS, we found a 19% non-significant increase in excitability changes in comparison with iTBS combined with sham TDCS. When the TDCS was reversed (anterior-posterior), the excitatory effect of iTBS was abolished. CONCLUSION: Our findings suggest that excitatory after-effects of iTBS can be modulated by directionally-specific TDCS. |
format | Online Article Text |
id | pubmed-5487022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54870222017-07-12 Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study Tremblay, Sara Hannah, Ricci Rawji, Vishal Rothwell, John C. Brain Stimul Article BACKGROUND: Polarising currents can modulate membrane potentials in animals, affecting the after-effect of theta burst stimulation (TBS) on synaptic strength. OBJECTIVE: We examined whether a similar phenomenon could also be observed in human motor cortex (M1) using transcranial direct current stimulation (TDCS) during monophasic intermittent TBS (iTBS). METHODS: TDCS was applied during posterior-anterior iTBS using three different conditions: posterior-anterior TDCS (anode 3.5 cm posterior to M1, cathode 3.5 cm anterior to M1), anterior-posterior TDCS (cathode 3.5 cm posterior to M1, anode 3.5 cm anterior to M1), and sham TDCS. RESULTS: When the direction of TDCS (posterior-anterior) matched the direction of the electrical field induced by iTBS, we found a 19% non-significant increase in excitability changes in comparison with iTBS combined with sham TDCS. When the TDCS was reversed (anterior-posterior), the excitatory effect of iTBS was abolished. CONCLUSION: Our findings suggest that excitatory after-effects of iTBS can be modulated by directionally-specific TDCS. Elsevier 2017 /pmc/articles/PMC5487022/ /pubmed/28404455 http://dx.doi.org/10.1016/j.brs.2017.03.009 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tremblay, Sara Hannah, Ricci Rawji, Vishal Rothwell, John C. Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study |
title | Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study |
title_full | Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study |
title_fullStr | Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study |
title_full_unstemmed | Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study |
title_short | Modulation of iTBS after-effects via concurrent directional TDCS: A proof of principle study |
title_sort | modulation of itbs after-effects via concurrent directional tdcs: a proof of principle study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487022/ https://www.ncbi.nlm.nih.gov/pubmed/28404455 http://dx.doi.org/10.1016/j.brs.2017.03.009 |
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