2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway

2,5-hexanedione (2,5-HD) is the main active metabolite of n-hexane and induces apoptosis in nerve tissue, however, the mechanism of which remains unclear. In the present study, neuropathic animal models were successfully constructed in rats by injecting 100, 200 and 400 mg/kg 2,5-HD intraperitoneall...

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Detalles Bibliográficos
Autores principales: Wang, Zhemin, Qiu, Zewen, Gao, Chenxue, Sun, Yijie, Dong, Wei, Zhang, Yan, Chen, Ruolin, Qi, Yuan, Li, Shuangyue, Guo, Yanjie, Piao, Yongjun, Li, Sheng, Piao, Fengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487034/
https://www.ncbi.nlm.nih.gov/pubmed/28654704
http://dx.doi.org/10.1371/journal.pone.0179388

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