Cargando…

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Gain-of-function mutations in KCNJ2-encoded Kir2.1 channels underlie variant 3 (SQT3) of the short QT syndrome, which is associated with atrial fibrillation (AF). Using biophysically-detailed human atria computer models, this study investigated the mechanistic link between SQT3 mutations and atrial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whittaker, Dominic G., Ni, Haibo, El Harchi, Aziza, Hancox, Jules C., Zhang, Henggui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487071/ https://www.ncbi.nlm.nih.gov/pubmed/28609477 http://dx.doi.org/10.1371/journal.pcbi.1005593

Ejemplares similares

Correction: Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria
Publicado: (2019)

In silico investigation of a KCNQ1 mutation associated with short QT syndrome
por: Adeniran, Ismail, et al.
Publicado: (2017)

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling
por: Whittaker, Dominic G., et al.
Publicado: (2018)

Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria
por: Colman, Michael A, et al.
Publicado: (2013)

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome
por: Whittaker, Dominic G., et al.
Publicado: (2019)

Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K(+) Channel
por: El Harchi, Aziza, et al.
Publicado: (2012)

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles
por: Whittaker, Dominic G., et al.
Publicado: (2017)

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome
por: El Harchi, Aziza, et al.
Publicado: (2009)

Modelling the effects of chloroquine on KCNJ2-linked short QT syndrome
por: Luo, Cunjin, et al.
Publicado: (2017)

Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics – Insights from a 3D Model of the Human Atria
por: Adeniran, Ismail, et al.
Publicado: (2015)

A New Algorithm to Diagnose Atrial Ectopic Origin from Multi Lead ECG Systems - Insights from 3D Virtual Human Atria and Torso
por: Alday, Erick A. Perez, et al.
Publicado: (2015)

Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition
por: Du, Chunyun, et al.
Publicado: (2013)

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling
por: Adeniran, Ismail, et al.
Publicado: (2013)

Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin
por: Ni, Haibo, et al.
Publicado: (2017)

Identification through action potential clamp of proarrhythmic consequences of the short QT syndrome T618I hERG ‘hotspot’ mutation
por: Du, Chunyun, et al.
Publicado: (2022)

Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome
por: Adeniran, Ismail, et al.
Publicado: (2011)

Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model
por: Colman, Michael A., et al.
Publicado: (2014)

Short QT interval as a harbinger of an arrhythmogenic cardiomyopathy
por: Chevalier, Philippe, et al.
Publicado: (2021)

Pharmacological activation of the hERG K(+) channel for the management of the long QT syndrome: A review
por: El Harchi, Aziza, et al.
Publicado: (2022)

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp
por: Du, Chunyun, et al.
Publicado: (2022)

Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration
por: Melgari, Dario, et al.
Publicado: (2014)

Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models
por: Alrabghi, Ghadah, et al.
Publicado: (2023)

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study
por: Alghamdi, Azzah M., et al.
Publicado: (2020)

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants
por: Du, Chunyun, et al.
Publicado: (2014)

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide
por: Melgari, Dario, et al.
Publicado: (2015)

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine
por: El Harchi, Aziza, et al.
Publicado: (2020)

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study
por: Wang, Wei, et al.
Publicado: (2018)

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue
por: Helliwell, Matthew V., et al.
Publicado: (2023)

Left ventricular noncompaction cardiomyopathy and short QT syndrome due to primary carnitine deficiency
por: Hanington, Oliver P., et al.
Publicado: (2023)

Structural implications of hERG K(+) channel block by a high-affinity minimally structured blocker
por: Helliwell, Matthew V., et al.
Publicado: (2018)

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome
por: Butler, Andrew, et al.
Publicado: (2019)

QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine
por: Malone, Katie, et al.
Publicado: (2020)

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome
por: Butler, Andrew, et al.
Publicado: (2018)

Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling – Insights From Computational Modelling
por: Jian, Kun, et al.
Publicado: (2022)

Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy
por: Gysel, Michael, et al.
Publicado: (2014)

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
por: Zhang, Yihong, et al.
Publicado: (2016)

Molecular Insights into Short QT Syndrome
por: Perike, Srikanth, et al.
Publicado: (2018)

Anatomy of the atria: A road map to the left atrial appendage
por: Barbero, Umberto, et al.
Publicado: (2017)

Effects of amiodarone on short QT syndrome variant 3 in human ventricles: a simulation study
por: Luo, Cunjin, et al.
Publicado: (2017)

Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling
por: Lee, Hsiang-Chun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ar2udfbvg2dp6rrpkhm7iul21k