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Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2
During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. How this transition is operated in vivo is poorly understood. Here, we report that MEK1 and the Nanog-related transcription factor Ventx2 coordinate this transition. MEK1 was required to make...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487210/ https://www.ncbi.nlm.nih.gov/pubmed/28654420 http://dx.doi.org/10.7554/eLife.21526 |