Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

The rate of protein synthesis in the adult heart is one of the lowest in mammalian tissues, but it increases substantially in response to stress and hypertrophic stimuli through largely obscure mechanisms. Here, we demonstrate that regulated expression of cytosolic poly(A)-binding protein 1 (PABPC1)...

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Detalles Bibliográficos
Autores principales: Chorghade, Sandip, Seimetz, Joseph, Emmons, Russell, Yang, Jing, Bresson, Stefan M, Lisio, Michael De, Parise, Gianni, Conrad, Nicholas K, Kalsotra, Auinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487213/
https://www.ncbi.nlm.nih.gov/pubmed/28653618
http://dx.doi.org/10.7554/eLife.24139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487213/
https://www.ncbi.nlm.nih.gov/pubmed/28653618
http://dx.doi.org/10.7554/eLife.24139

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