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Toll-like Receptor 4 Mediates Fat, Sugar and Umami Taste Preference, and Food Intake and Body Weight Regulation

OBJECTIVE: Immune and inflammatory pathways play important roles in the pathogenesis of metabolic disorders. In the present study we investigate the role of TLR4 in orosensory detection of dietary lipids and sugars. METHODS: Taste preferences of TLR4 knockout (KO) and wild type (WT) male mice under...

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Autores principales: Camandola, Simonetta, Mattson, Mark P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487280/
https://www.ncbi.nlm.nih.gov/pubmed/28500692
http://dx.doi.org/10.1002/oby.21871
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author Camandola, Simonetta
Mattson, Mark P.
author_facet Camandola, Simonetta
Mattson, Mark P.
author_sort Camandola, Simonetta
collection PubMed
description OBJECTIVE: Immune and inflammatory pathways play important roles in the pathogenesis of metabolic disorders. In the present study we investigate the role of TLR4 in orosensory detection of dietary lipids and sugars. METHODS: Taste preferences of TLR4 knockout (KO) and wild type (WT) male mice under standard, and high fat and high sugar diets were assessed with 2-bottle tests. Gene expression of taste signaling molecules was analyzed in the tongue epithelium The role of TLR4 in food intake, and weigh gain was investigated in TLR4 KO and WT mice fed a high fat and high sugar diet for 12 weeks. RESULTS: Compared to WT mice TLR4 KO mice showed reduced preference for lipids, sugars, and umami in 2-bottle preference test. The altered taste perception was associated with decreased levels of key taste regulatory molecules in the tongue epithelium. TLR4 KO mice on a high fat and high sugar diet consumed less food and drink, resulting in diminished weight gain. CONCLUSIONS: TLR4 signaling promotes ingestion of sugar and fat by a mechanism involving increased preference for such obesogenic foods.
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spelling pubmed-54872802017-11-12 Toll-like Receptor 4 Mediates Fat, Sugar and Umami Taste Preference, and Food Intake and Body Weight Regulation Camandola, Simonetta Mattson, Mark P. Obesity (Silver Spring) Article OBJECTIVE: Immune and inflammatory pathways play important roles in the pathogenesis of metabolic disorders. In the present study we investigate the role of TLR4 in orosensory detection of dietary lipids and sugars. METHODS: Taste preferences of TLR4 knockout (KO) and wild type (WT) male mice under standard, and high fat and high sugar diets were assessed with 2-bottle tests. Gene expression of taste signaling molecules was analyzed in the tongue epithelium The role of TLR4 in food intake, and weigh gain was investigated in TLR4 KO and WT mice fed a high fat and high sugar diet for 12 weeks. RESULTS: Compared to WT mice TLR4 KO mice showed reduced preference for lipids, sugars, and umami in 2-bottle preference test. The altered taste perception was associated with decreased levels of key taste regulatory molecules in the tongue epithelium. TLR4 KO mice on a high fat and high sugar diet consumed less food and drink, resulting in diminished weight gain. CONCLUSIONS: TLR4 signaling promotes ingestion of sugar and fat by a mechanism involving increased preference for such obesogenic foods. 2017-05-12 2017-07 /pmc/articles/PMC5487280/ /pubmed/28500692 http://dx.doi.org/10.1002/oby.21871 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Camandola, Simonetta
Mattson, Mark P.
Toll-like Receptor 4 Mediates Fat, Sugar and Umami Taste Preference, and Food Intake and Body Weight Regulation
title Toll-like Receptor 4 Mediates Fat, Sugar and Umami Taste Preference, and Food Intake and Body Weight Regulation
title_full Toll-like Receptor 4 Mediates Fat, Sugar and Umami Taste Preference, and Food Intake and Body Weight Regulation
title_fullStr Toll-like Receptor 4 Mediates Fat, Sugar and Umami Taste Preference, and Food Intake and Body Weight Regulation
title_full_unstemmed Toll-like Receptor 4 Mediates Fat, Sugar and Umami Taste Preference, and Food Intake and Body Weight Regulation
title_short Toll-like Receptor 4 Mediates Fat, Sugar and Umami Taste Preference, and Food Intake and Body Weight Regulation
title_sort toll-like receptor 4 mediates fat, sugar and umami taste preference, and food intake and body weight regulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487280/
https://www.ncbi.nlm.nih.gov/pubmed/28500692
http://dx.doi.org/10.1002/oby.21871
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