Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion

Chronic cerebral hypoperfusion is a major cause of age-related vascular cognitive impairment. A well-characterised mouse model has shown that hypoperfusion results in gliovascular and white matter damage and impaired spatial working memory. In this study, we assessed whether cilostazol, a phosphodie...

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Detalles Bibliográficos
Autores principales: Kitamura, Akihiro, Manso, Yasmina, Duncombe, Jessica, Searcy, James, Koudelka, Juraj, Binnie, Margaret, Webster, Scott, Lennen, Ross, Jansen, Maurits, Marshall, Ian, Ihara, Masafumi, Kalaria, Raj N., Horsburgh, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487324/
https://www.ncbi.nlm.nih.gov/pubmed/28655874
http://dx.doi.org/10.1038/s41598-017-04082-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487324/
https://www.ncbi.nlm.nih.gov/pubmed/28655874
http://dx.doi.org/10.1038/s41598-017-04082-0

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