Cargando…

Direct conversion of human fibroblasts to brown adipocytes by small chemical compounds

Brown adipocytes play an important role in human energy metabolism and prevention of obesity and diabetes. Induced pluripotent stem cells (iPSCs) represent a promising source for brown adipocytes; however, exogenous gene induction is generally required for iPSCs generation, which might cause undesir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takeda, Yukimasa, Harada, Yoshinori, Yoshikawa, Toshikazu, Dai, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487346/ https://www.ncbi.nlm.nih.gov/pubmed/28655922 http://dx.doi.org/10.1038/s41598-017-04665-x

Ejemplares similares

Transcriptome analysis reveals brown adipogenic reprogramming in chemical compound-induced brown adipocytes converted from human dermal fibroblasts
por: Takeda, Yukimasa, et al.
Publicado: (2021)

Capsaicin directly promotes adipocyte browning in the chemical compound-induced brown adipocytes converted from human dermal fibroblasts
por: Takeda, Yukimasa, et al.
Publicado: (2022)

A developed serum-free medium and an optimized chemical cocktail for direct conversion of human dermal fibroblasts into brown adipocytes
por: Takeda, Yukimasa, et al.
Publicado: (2020)

Chemical compound-based direct reprogramming for future clinical applications
por: Takeda, Yukimasa, et al.
Publicado: (2018)

Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases
por: Takeda, Yukimasa, et al.
Publicado: (2023)

Highly efficient direct conversion of human fibroblasts to neuronal cells by chemical compounds
por: Dai, Ping, et al.
Publicado: (2015)

Chronic Fatty Acid Depletion Induces Uncoupling Protein 1 (UCP1) Expression to Coordinate Mitochondrial Inducible Proton Leak in a Human-Brown-Adipocyte Model
por: Takeda, Yukimasa, et al.
Publicado: (2022)

Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model
por: Kurahashi, Toshihiro, et al.
Publicado: (2023)

Direct Conversion of Human Fibroblasts into Adipocytes Using a Novel Small Molecular Compound: Implications for Regenerative Therapy for Adipose Tissue Defects
por: Sowa, Yoshihiro, et al.
Publicado: (2021)

Direct conversion of human myoblasts into brown-like adipocytes by engineered superactive PPARγ
por: Zhu, Yanbei, et al.
Publicado: (2015)

Bioactive Compounds and Adipocyte Browning Phenomenon
por: Manríquez-Núñez, Josué, et al.
Publicado: (2022)

White-to-brown metabolic conversion of human adipocytes by JAK inhibition
por: Moisan, Annie, et al.
Publicado: (2014)

Rapid direct conversion of bovine non-adipogenic fibroblasts into adipocyte-like cells by a small-molecule cocktail
por: Sun, Longfei, et al.
Publicado: (2023)

Small molecules increase direct neural conversion of human fibroblasts
por: Pfisterer, Ulrich, et al.
Publicado: (2016)

Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts
por: El-Hattab, Mariam Y., et al.
Publicado: (2020)

Direct conversion of osteosarcoma to adipocytes by targeting TNIK
por: Hirozane, Toru, et al.
Publicado: (2021)

Brown adipogenic potential of brown adipocytes and peri-renal adipocytes from human embryo
por: Wu, Nan-Nan, et al.
Publicado: (2016)

Direct Evidence of Brown Adipocytes in Different Fat Depots in Children
por: Rockstroh, Denise, et al.
Publicado: (2015)

The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe
por: Kimura, Haruka, et al.
Publicado: (2017)

The Therapeutic Potential of Brown Adipocytes in Humans
por: Porter, Craig, et al.
Publicado: (2015)

SAT-584 Uc.336-As Inhibits White Adipocyte Differentiation and Promotes White to Brown Conversion
por: Li, Yanbing, et al.
Publicado: (2020)

Native adiponectin plays a role in the adipocyte-mediated conversion of fibroblasts to myofibroblasts
por: El-Hattab, Mariam Y., et al.
Publicado: (2023)

Chemical Conversion of Human Fibroblasts into Functional Schwann Cells
por: Thoma, Eva C., et al.
Publicado: (2014)

Chemical conversion of human lung fibroblasts into neuronal cells
por: Wan, Xiao-Yu, et al.
Publicado: (2018)

Loading and firing the brown adipocyte
por: Hankir, Mohammed K.
Publicado: (2017)

Small molecular compounds efficiently convert human fibroblasts directly into neurons
por: Yang, Jijuan, et al.
Publicado: (2020)

ASK1 signalling regulates brown and beige adipocyte function
por: Hattori, Kazuki, et al.
Publicado: (2016)

Direct conversion of human fibroblasts to induced serotonergic neurons
por: Xu, Z, et al.
Publicado: (2016)

Adipocytes and Stromal Cells Regulate Brown Adipogenesis Through Secretory Factors During the Postnatal White-to-Brown Conversion of Adipose Tissue in Syrian Hamsters
por: Mae, Junnosuke, et al.
Publicado: (2021)

Direct Conversion of Mouse Fibroblasts into Cholangiocyte Progenitor Cells
por: Lim, Kyung Tae, et al.
Publicado: (2018)

Mitochondria in White, Brown, and Beige Adipocytes
por: Cedikova, Miroslava, et al.
Publicado: (2016)

The Mechanism of White and Brown Adipocyte Differentiation
por: Nakagami, Hironori
Publicado: (2013)

Cinnamon induces browning in subcutaneous adipocytes
por: Kwan, Hiu Yee, et al.
Publicado: (2017)

Effects of exercise on brown and beige adipocytes()
por: Dewal, Revati S., et al.
Publicado: (2018)

Lipid Transport in Brown Adipocyte Thermogenesis
por: Wade, Gina, et al.
Publicado: (2021)

Epigenetic Regulators of White Adipocyte Browning
por: Nanduri, Ravikanth
Publicado: (2021)

Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons by Small Molecules
por: Yang, Yaming, et al.
Publicado: (2019)

Direct conversion of adult fibroblasts into motor neurons
por: Sepehrimanesh, Masood, et al.
Publicado: (2021)

The impact of metabolic endotoxaemia on the browning process in human adipocytes
por: Omran, Farah, et al.
Publicado: (2023)

Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors
por: Qin, Hua, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_09p4ct76k8jebe1gc3jnkvki51