Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis. CD300f (−/−) mice were protected from death after cecal lig...

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Detalles Bibliográficos
Autores principales: Izawa, Kumi, Maehara, Akie, Isobe, Masamichi, Yasuda, Yuka, Urai, Makoto, Hoshino, Yasutaka, Ueno, Keigo, Matsukawa, Toshihiro, Takahashi, Mariko, Kaitani, Ayako, Shiba, Emiko, Takamori, Ayako, Uchida, Shino, Uchida, Koichiro, Maeda, Keiko, Nakano, Nobuhiro, Yamanishi, Yoshinori, Oki, Toshihiko, Voehringer, David, Roers, Axel, Nakae, Susumu, Ishikawa, Junko, Kinjo, Yuki, Shimizu, Toshiaki, Ogawa, Hideoki, Okumura, Ko, Kitamura, Toshio, Kitaura, Jiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487349/
https://www.ncbi.nlm.nih.gov/pubmed/28655892
http://dx.doi.org/10.1038/s41598-017-04647-z

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