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Astrocyte Activation in Locus Coeruleus Is Involved in Neuropathic Pain Exacerbation Mediated by Maternal Separation and Social Isolation Stress

Our previous studies demonstrated that emotional dysfunction associated with early life stress exacerbated nerve injury-induced mechanical allodynia. Sex differences were observed in several anxiety tests, but not in mechanical allodynia. To elucidate the mechanism underlying these findings, we have...

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Detalles Bibliográficos
Autores principales: Nakamoto, Kazuo, Aizawa, Fuka, Kinoshita, Megumi, Koyama, Yutaka, Tokuyama, Shogo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487383/
https://www.ncbi.nlm.nih.gov/pubmed/28701953
http://dx.doi.org/10.3389/fphar.2017.00401