An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol

Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its beneficial neuroprotective, antiepileptic, anxiolytic...

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Detalles Bibliográficos
Autores principales: Morales, Paula, Reggio, Patricia H., Jagerovic, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487438/
https://www.ncbi.nlm.nih.gov/pubmed/28701957
http://dx.doi.org/10.3389/fphar.2017.00422
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author Morales, Paula
Reggio, Patricia H.
Jagerovic, Nadine
author_facet Morales, Paula
Reggio, Patricia H.
Jagerovic, Nadine
author_sort Morales, Paula
collection PubMed
description Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its beneficial neuroprotective, antiepileptic, anxiolytic, antipsychotic, and anti-inflammatory properties. Therefore, the CBD scaffold becomes of increasing interest for medicinal chemists. This review provides an overview of the chemical structure of natural and synthetic CBD derivatives including the molecular targets associated with these compounds. A clear identification of their biological targets has been shown to be still very challenging.
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spelling pubmed-54874382017-07-12 An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol Morales, Paula Reggio, Patricia H. Jagerovic, Nadine Front Pharmacol Pharmacology Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its beneficial neuroprotective, antiepileptic, anxiolytic, antipsychotic, and anti-inflammatory properties. Therefore, the CBD scaffold becomes of increasing interest for medicinal chemists. This review provides an overview of the chemical structure of natural and synthetic CBD derivatives including the molecular targets associated with these compounds. A clear identification of their biological targets has been shown to be still very challenging. Frontiers Media S.A. 2017-06-28 /pmc/articles/PMC5487438/ /pubmed/28701957 http://dx.doi.org/10.3389/fphar.2017.00422 Text en Copyright © 2017 Morales, Reggio and Jagerovic. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Morales, Paula
Reggio, Patricia H.
Jagerovic, Nadine
An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
title An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
title_full An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
title_fullStr An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
title_full_unstemmed An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
title_short An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
title_sort overview on medicinal chemistry of synthetic and natural derivatives of cannabidiol
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487438/
https://www.ncbi.nlm.nih.gov/pubmed/28701957
http://dx.doi.org/10.3389/fphar.2017.00422
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