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Comparing reduced-dose sodium phosphate tablets to 2 L of polyethylene glycol: A randomized study

AIM: To compare the tolerability and quality of bowel cleansing between 2 L polyethylene glycol (PEG) and reduced-dose sodium phosphate (NaP) tablets as a preparation for colonoscopy. METHODS: Two hundred patients were randomly assigned to the PEG or NaP groups at the same ratio. The NaP group patie...

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Detalles Bibliográficos
Autores principales: Ako, Soichiro, Takemoto, Koji, Yasutomi, Eriko, Sakaguchi, Chihiro, Murakami, Mayu, Sunami, Tomoko, Oka, Shohei, Kenta, Hamada, Okazaki, Noriko, Baba, Yuki, Yamasaki, Yasushi, Asato, Toshiyuki, Kawai, Daisuke, Takenaka, Ryuta, Tsugeno, Hirohumi, Hiraoka, Sakiko, Kato, Jun, Fujiki, Shigeatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487510/
https://www.ncbi.nlm.nih.gov/pubmed/28706429
http://dx.doi.org/10.3748/wjg.v23.i24.4454
Descripción
Sumario:AIM: To compare the tolerability and quality of bowel cleansing between 2 L polyethylene glycol (PEG) and reduced-dose sodium phosphate (NaP) tablets as a preparation for colonoscopy. METHODS: Two hundred patients were randomly assigned to the PEG or NaP groups at the same ratio. The NaP group patients took 30 tablets with 2 L of clear liquid, while the PEG group patients took 2L of PEG. Tolerability was assessed by a questionnaire about taste, volume, and the overall impression. The bowel cleansing quality was evaluated by colonoscopists. RESULTS: Although NaP showed better tolerability in terms of taste, volume and overall impression (P < 0.01, P < 0.01 and P = 0.02, respectively), the overall cleansing quality was better in the PEG group (P < 0.01). A subgroup analysis, stratified by sex and age, indicated that NaP was associated with better tolerability and equivalent bowel cleansing quality in females of < 50 years of age. CONCLUSION: Despite the better tolerability, the use of 30 NaP tablets with 2 L of clear liquid should be limited due to its lower cleansing quality; however, in certain cases the regimen may deserve consideration, particularly in cases involving young women.