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Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study
Objective: The objective of this study was to investigate resting-state functional connectivity (FC) differences in insular sub-regions during the interictal phase in patients with migraine without aura (MWoA). Methods: Forty-nine MWoA patients (MWoA group) and 48 healthy individuals (healthy contro...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487515/ https://www.ncbi.nlm.nih.gov/pubmed/28701932 http://dx.doi.org/10.3389/fnbeh.2017.00124 |
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author | Yu, Zhi-bo Lv, Yan-bing Song, Ling-heng Liu, Dai-hong Huang, Xue-ling Hu, Xin-yue Zuo, Zhi-wei Wang, Yao Yang, Qian Peng, Jing Zhou, Zhen-hua Li, Hai-tao |
author_facet | Yu, Zhi-bo Lv, Yan-bing Song, Ling-heng Liu, Dai-hong Huang, Xue-ling Hu, Xin-yue Zuo, Zhi-wei Wang, Yao Yang, Qian Peng, Jing Zhou, Zhen-hua Li, Hai-tao |
author_sort | Yu, Zhi-bo |
collection | PubMed |
description | Objective: The objective of this study was to investigate resting-state functional connectivity (FC) differences in insular sub-regions during the interictal phase in patients with migraine without aura (MWoA). Methods: Forty-nine MWoA patients (MWoA group) and 48 healthy individuals (healthy control group) were recruited for this study. All of the subjects underwent neurological examination and magnetic resonance imaging (MRI). The MRI data were processed using Brat 1.0 software to obtain a whole-brain FC diagram and using Rest 1.8 software to obtain the FC z-score of the sub-regions of both insulas (six sub-regions on each side). Therefore, there were a total of 12 regions of interest (ROIs) that were used as seed points for the statistical analysis. Results: There was abnormal FC between the insular sub-regions and multiple brain regions in the MWoA patients compared with the healthy control group, and a clear laterality was also observed. In addition, the FC z-score of certain sub-regions was negatively correlated with the disease duration. Conclusion: Different insular sub-regions are functionally associated with different regions of the brain and therefore have different functions. In MWoA, the FC between the insular sub-regions and other brain regions was mostly reduced, while a small amount was increased; additionally, the FC may be ipsilateral with a right-side advantage. Variations in the FC of insular sub-regions can be observed as an important indicator of MWoA. |
format | Online Article Text |
id | pubmed-5487515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54875152017-07-12 Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study Yu, Zhi-bo Lv, Yan-bing Song, Ling-heng Liu, Dai-hong Huang, Xue-ling Hu, Xin-yue Zuo, Zhi-wei Wang, Yao Yang, Qian Peng, Jing Zhou, Zhen-hua Li, Hai-tao Front Behav Neurosci Neuroscience Objective: The objective of this study was to investigate resting-state functional connectivity (FC) differences in insular sub-regions during the interictal phase in patients with migraine without aura (MWoA). Methods: Forty-nine MWoA patients (MWoA group) and 48 healthy individuals (healthy control group) were recruited for this study. All of the subjects underwent neurological examination and magnetic resonance imaging (MRI). The MRI data were processed using Brat 1.0 software to obtain a whole-brain FC diagram and using Rest 1.8 software to obtain the FC z-score of the sub-regions of both insulas (six sub-regions on each side). Therefore, there were a total of 12 regions of interest (ROIs) that were used as seed points for the statistical analysis. Results: There was abnormal FC between the insular sub-regions and multiple brain regions in the MWoA patients compared with the healthy control group, and a clear laterality was also observed. In addition, the FC z-score of certain sub-regions was negatively correlated with the disease duration. Conclusion: Different insular sub-regions are functionally associated with different regions of the brain and therefore have different functions. In MWoA, the FC between the insular sub-regions and other brain regions was mostly reduced, while a small amount was increased; additionally, the FC may be ipsilateral with a right-side advantage. Variations in the FC of insular sub-regions can be observed as an important indicator of MWoA. Frontiers Media S.A. 2017-06-28 /pmc/articles/PMC5487515/ /pubmed/28701932 http://dx.doi.org/10.3389/fnbeh.2017.00124 Text en Copyright © 2017 Yu, Lv, Song, Liu, Huang, Hu, Zuo, Wang, Yang, Peng, Zhou and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Yu, Zhi-bo Lv, Yan-bing Song, Ling-heng Liu, Dai-hong Huang, Xue-ling Hu, Xin-yue Zuo, Zhi-wei Wang, Yao Yang, Qian Peng, Jing Zhou, Zhen-hua Li, Hai-tao Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study |
title | Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study |
title_full | Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study |
title_fullStr | Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study |
title_full_unstemmed | Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study |
title_short | Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magnetic Resonance Imaging Study |
title_sort | functional connectivity differences in the insular sub-regions in migraine without aura: a resting-state functional magnetic resonance imaging study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487515/ https://www.ncbi.nlm.nih.gov/pubmed/28701932 http://dx.doi.org/10.3389/fnbeh.2017.00124 |
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