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Choosing Cell Fate Through a Dynamic Cell Cycle

A close relationship between proliferation and cell fate specification has been well documented in many developmental systems. In addition to the gradual cell fate changes accompanying normal development and tissue homeostasis, it is now commonly appreciated that cell fate could also undergo drastic...

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Autores principales: Chen, Xinyue, Hartman, Amaleah, Guo, Shangqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487535/
https://www.ncbi.nlm.nih.gov/pubmed/28725536
http://dx.doi.org/10.1007/s40778-015-0018-0
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author Chen, Xinyue
Hartman, Amaleah
Guo, Shangqin
author_facet Chen, Xinyue
Hartman, Amaleah
Guo, Shangqin
author_sort Chen, Xinyue
collection PubMed
description A close relationship between proliferation and cell fate specification has been well documented in many developmental systems. In addition to the gradual cell fate changes accompanying normal development and tissue homeostasis, it is now commonly appreciated that cell fate could also undergo drastic changes, as illustrated by the induction of pluripotency from many differentiated somatic cell types during the process of Yamanaka reprogramming. Strikingly, the drastic cell fate change induced by Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc) is preceded by extensive cell cycle acceleration. Prompted by our recent discovery that progression toward pluripotency from rare somatic cells could bypass the stochastic phase of reprogramming and that a key feature of these somatic cells is an ultrafast cell cycle (~8 h/cycle), we assess whether cell cycle dynamics could provide a general framework for controlling cell fate. Several potential mechanisms on how cell cycle dynamics may impact cell fate determination by regulating chromatin, key transcription factor concentration, or their interactions are discussed. Specific challenges and implications for studying and manipulating cell fate are considered.
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spelling pubmed-54875352017-07-17 Choosing Cell Fate Through a Dynamic Cell Cycle Chen, Xinyue Hartman, Amaleah Guo, Shangqin Curr Stem Cell Rep Stem Cell Switches and Regulators (KK Hirschi, Section Editor) A close relationship between proliferation and cell fate specification has been well documented in many developmental systems. In addition to the gradual cell fate changes accompanying normal development and tissue homeostasis, it is now commonly appreciated that cell fate could also undergo drastic changes, as illustrated by the induction of pluripotency from many differentiated somatic cell types during the process of Yamanaka reprogramming. Strikingly, the drastic cell fate change induced by Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc) is preceded by extensive cell cycle acceleration. Prompted by our recent discovery that progression toward pluripotency from rare somatic cells could bypass the stochastic phase of reprogramming and that a key feature of these somatic cells is an ultrafast cell cycle (~8 h/cycle), we assess whether cell cycle dynamics could provide a general framework for controlling cell fate. Several potential mechanisms on how cell cycle dynamics may impact cell fate determination by regulating chromatin, key transcription factor concentration, or their interactions are discussed. Specific challenges and implications for studying and manipulating cell fate are considered. Springer International Publishing 2015-07-01 2015 /pmc/articles/PMC5487535/ /pubmed/28725536 http://dx.doi.org/10.1007/s40778-015-0018-0 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Stem Cell Switches and Regulators (KK Hirschi, Section Editor)
Chen, Xinyue
Hartman, Amaleah
Guo, Shangqin
Choosing Cell Fate Through a Dynamic Cell Cycle
title Choosing Cell Fate Through a Dynamic Cell Cycle
title_full Choosing Cell Fate Through a Dynamic Cell Cycle
title_fullStr Choosing Cell Fate Through a Dynamic Cell Cycle
title_full_unstemmed Choosing Cell Fate Through a Dynamic Cell Cycle
title_short Choosing Cell Fate Through a Dynamic Cell Cycle
title_sort choosing cell fate through a dynamic cell cycle
topic Stem Cell Switches and Regulators (KK Hirschi, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487535/
https://www.ncbi.nlm.nih.gov/pubmed/28725536
http://dx.doi.org/10.1007/s40778-015-0018-0
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