Cargando…

Mouse Saliva Inhibits Transit of Influenza Virus to the Lower Respiratory Tract by Efficiently Blocking Influenza Virus Neuraminidase Activity

We previously identified a novel inhibitor of influenza virus in mouse saliva that halts the progression of susceptible viruses from the upper to the lower respiratory tract of mice in vivo and neutralizes viral infectivity in MDCK cells. Here, we investigated the viral target of the salivary inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gilbertson, Brad, Ng, Wy Ching, Crawford, Simon, McKimm-Breschkin, Jenny L., Brown, Lorena E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487565/ https://www.ncbi.nlm.nih.gov/pubmed/28446666 http://dx.doi.org/10.1128/JVI.00145-17

Ejemplares similares

Influenza Virus Neuraminidase Structure and Functions
por: McAuley, Julie L., et al.
Publicado: (2019)

Hemagglutinin and Neuraminidase Antibodies Are Induced in an Age- and Subtype-Dependent Manner after Influenza Virus Infection
por: Wong, Sook-San, et al.
Publicado: (2020)

Management of Influenza Virus Infections with Neuraminidase Inhibitors: Detection, Incidence, and Implications of Drug Resistance
por: McKimm-Breschkin, Jennifer L.
Publicado: (2012)

Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background
por: Shin, Dai-Lun, et al.
Publicado: (2015)

Chicken and Duck Myotubes Are Highly Susceptible and Permissive to Influenza Virus Infection
por: Baquero-Perez, Belinda, et al.
Publicado: (2014)

Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques
por: Chan, Mable, et al.
Publicado: (2022)

A Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses
por: Bae, Joon-Yong, et al.
Publicado: (2018)

Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System
por: Siegers, Jurre Y., et al.
Publicado: (2019)

Utility of Human In Vitro Data in Risk Assessments of Influenza A Virus Using the Ferret Model
por: Creager, Hannah M., et al.
Publicado: (2023)

Mutation of Influenza A Virus PA-X Decreases Pathogenicity in Chicken Embryos and Can Increase the Yield of Reassortant Candidate Vaccine Viruses
por: Hussain, Saira, et al.
Publicado: (2019)

Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity
por: Turnbull, Matthew L., et al.
Publicado: (2016)

Contribution of Segment 3 to the Acquisition of Virulence in Contemporary H9N2 Avian Influenza Viruses
por: Clements, Anabel L., et al.
Publicado: (2020)

Pathobiology of an NS1-Truncated H3N2 Swine Influenza Virus Strain in Pigs
por: Vandoorn, Elien, et al.
Publicado: (2022)

Levels of Influenza A Virus Defective Viral Genomes Determine Pathogenesis in the BALB/c Mouse Model
por: Penn, Rebecca, et al.
Publicado: (2022)

Tick Saliva Enhances Powassan Virus Transmission to the Host, Influencing Its Dissemination and the Course of Disease
por: Hermance, Meghan E., et al.
Publicado: (2015)

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses†
por: Oakley, Aaron J., et al.
Publicado: (2010)

CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo
por: Teng, Ooiean, et al.
Publicado: (2016)

Assessing the Protective Potential of H1N1 Influenza Virus Hemagglutinin Head and Stalk Antibodies in Humans
por: Christensen, Shannon R., et al.
Publicado: (2019)

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice
por: Feng, Xiaoxiao, et al.
Publicado: (2016)

The neuraminidases of MDCK grown human influenza A(H3N2) viruses isolated since 1994 can demonstrate receptor binding
por: Mohr, Peter G, et al.
Publicado: (2015)

Real Time Enzyme Inhibition Assays Provide Insights into Differences in Binding of Neuraminidase Inhibitors to Wild Type and Mutant Influenza Viruses
por: Barrett, Susan, et al.
Publicado: (2011)

Varying Viral Replication and Disease Profiles of H2N2 Influenza in Ferrets Is Associated with Virus Isolate and Inoculation Route
por: van de Ven, Koen, et al.
Publicado: (2022)

Characterization of an Emergent Chicken H3N8 Influenza Virus in Southern China: a Potential Threat to Public Health
por: Chen, Peiwen, et al.
Publicado: (2023)

The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases
por: Kühn, Nora, et al.
Publicado: (2016)

Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response
por: Zhao, Dongming, et al.
Publicado: (2017)

Long-Term Protective Effect of Serial Infections with H5N8 Highly Pathogenic Avian Influenza Virus in Wild Ducks
por: Caliendo, Valentina, et al.
Publicado: (2022)

The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
por: Xiao, Han, et al.
Publicado: (2013)

Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals
por: Arai, Yasuha, et al.
Publicado: (2019)

IRF5 Promotes Influenza Virus-Induced Inflammatory Responses in Human Induced Pluripotent Stem Cell-Derived Myeloid Cells and Murine Models
por: Forbester, Jessica L., et al.
Publicado: (2020)

Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4(+) T Cell Responses
por: Kim, Eun-Ha, et al.
Publicado: (2022)

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses
por: DeDiego, Marta L., et al.
Publicado: (2016)

A Single Amino Acid at Position 431 of the PB2 Protein Determines the Virulence of H1N1 Swine Influenza Viruses in Mice
por: Xu, Chengzhi, et al.
Publicado: (2020)

PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range
por: Arai, Yasuha, et al.
Publicado: (2020)

The Activation of the RIG-I/MDA5 Signaling Pathway upon Influenza D Virus Infection Impairs the Pulmonary Proinflammatory Response Triggered by Mycoplasma bovis Superinfection
por: Gaudino, Maria, et al.
Publicado: (2023)

A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence
por: Ayllon, Juan, et al.
Publicado: (2014)

A Single-Amino-Acid Substitution at Position 225 in Hemagglutinin Alters the Transmissibility of Eurasian Avian-Like H1N1 Swine Influenza Virus in Guinea Pigs
por: Wang, Zeng, et al.
Publicado: (2017)

Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics
por: Peacock, Thomas P., et al.
Publicado: (2017)

A Generic System for the Expression and Purification of Soluble and Stable Influenza Neuraminidase
por: Schmidt, Peter M., et al.
Publicado: (2011)

Virus and Host Factors Affecting the Clinical Outcome of Bluetongue Virus Infection
por: Caporale, Marco, et al.
Publicado: (2014)

Expanding Regulatory T Cells Alleviates Chikungunya Virus-Induced Pathology in Mice
por: Lee, Wendy W. L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cgk1vssmo3mkdd1ed5uk62bj8d