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Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis

Variable exposure to antituberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area under the concentration-time curve (AUC) of rifampin. We evaluated the contributi...

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Detalles Bibliográficos
Autores principales:	Sloan, Derek J., McCallum, Andrew D., Schipani, Alessandro, Egan, Deirdre, Mwandumba, Henry C., Ward, Steve A., Waterhouse, David, Banda, Gertrude, Allain, Theresa J., Owen, Andrew, Khoo, Saye H., Davies, Geraint R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Clinical Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487625/ https://www.ncbi.nlm.nih.gov/pubmed/28461315 http://dx.doi.org/10.1128/AAC.00210-17

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