Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway

Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by...

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Detalles Bibliográficos
Autores principales: Hegyi, Eszter, Sahin-Tóth, Miklós
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487703/
https://www.ncbi.nlm.nih.gov/pubmed/28536777
http://dx.doi.org/10.1007/s10620-017-4601-3
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author Hegyi, Eszter
Sahin-Tóth, Miklós
author_facet Hegyi, Eszter
Sahin-Tóth, Miklós
author_sort Hegyi, Eszter
collection PubMed
description Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by stimulation of autoactivation or by impairing protective trypsinogen degradation and/or trypsin inhibition. Here we review key genetic and biochemical features of the trypsin-dependent pathological pathway in chronic pancreatitis.
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spelling pubmed-54877032017-07-03 Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway Hegyi, Eszter Sahin-Tóth, Miklós Dig Dis Sci Review Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by stimulation of autoactivation or by impairing protective trypsinogen degradation and/or trypsin inhibition. Here we review key genetic and biochemical features of the trypsin-dependent pathological pathway in chronic pancreatitis. Springer US 2017-05-23 2017 /pmc/articles/PMC5487703/ /pubmed/28536777 http://dx.doi.org/10.1007/s10620-017-4601-3 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Hegyi, Eszter
Sahin-Tóth, Miklós
Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
title Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
title_full Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
title_fullStr Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
title_full_unstemmed Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
title_short Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
title_sort genetic risk in chronic pancreatitis: the trypsin-dependent pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487703/
https://www.ncbi.nlm.nih.gov/pubmed/28536777
http://dx.doi.org/10.1007/s10620-017-4601-3
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