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Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487703/ https://www.ncbi.nlm.nih.gov/pubmed/28536777 http://dx.doi.org/10.1007/s10620-017-4601-3 |