Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by (19)F-NMR observation of 4-fluorophenylalanine

The amino acid 4-fluoro-l-phenylalanine (4F-Phe) was introduced at the positions of Phe6 and Phe22 in the 29-residue polypeptide hormone glucagon by expressing glucagon in E. coli in the presence of an excess of 4F-Phe. Glucagon regulates blood glucose homeostasis by interaction with the glucagon re...

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Detalles Bibliográficos
Autores principales: Hou, Yaguang, Hu, Wanhui, Li, Xiaona, Skinner, John J., Liu, Dongsheng, Wüthrich, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487752/
https://www.ncbi.nlm.nih.gov/pubmed/28508109
http://dx.doi.org/10.1007/s10858-017-0107-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487752/
https://www.ncbi.nlm.nih.gov/pubmed/28508109
http://dx.doi.org/10.1007/s10858-017-0107-8

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