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Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP

The bile salt export pump (BSEP) actively transports conjugated monovalent bile acids from the hepatocytes into the bile. This facilitates the formation of micelles and promotes digestion and absorption of dietary fat. Inhibition of BSEP leads to decreased bile flow and accumulation of cytotoxic bil...

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Detalles Bibliográficos
Autores principales:	Jain, Sankalp, Grandits, Melanie, Richter, Lars, Ecker, Gerhard F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487762/ https://www.ncbi.nlm.nih.gov/pubmed/28527154 http://dx.doi.org/10.1007/s10822-017-0021-x

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