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NK1.1(−) CD4(+) NKG2D(+) T cells suppress DSS‐induced colitis in mice through production of TGF‐β

CD4(+) NKG2D(+) T cells are associated with tumour, infection and autoimmune diseases. Some CD4(+) NKG2D(+) T cells secrete IFN‐γ and TNF‐α to promote inflammation, but others produce TGF‐β and FasL to facilitate tumour evasion. Here, murine CD4(+) NKG2D(+) T cells were further classified into NK1.1...

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Autores principales: Qian, Xingxing, Hu, Chunxia, Han, Sen, Lin, Zhijie, Xiao, Weiming, Ding, Yanbing, Zhang, Yu, Qian, Li, Jia, Xiaoqing, Zhu, Guoqiang, Gong, Weijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487917/
https://www.ncbi.nlm.nih.gov/pubmed/28224733
http://dx.doi.org/10.1111/jcmm.13072
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author Qian, Xingxing
Hu, Chunxia
Han, Sen
Lin, Zhijie
Xiao, Weiming
Ding, Yanbing
Zhang, Yu
Qian, Li
Jia, Xiaoqing
Zhu, Guoqiang
Gong, Weijuan
author_facet Qian, Xingxing
Hu, Chunxia
Han, Sen
Lin, Zhijie
Xiao, Weiming
Ding, Yanbing
Zhang, Yu
Qian, Li
Jia, Xiaoqing
Zhu, Guoqiang
Gong, Weijuan
author_sort Qian, Xingxing
collection PubMed
description CD4(+) NKG2D(+) T cells are associated with tumour, infection and autoimmune diseases. Some CD4(+) NKG2D(+) T cells secrete IFN‐γ and TNF‐α to promote inflammation, but others produce TGF‐β and FasL to facilitate tumour evasion. Here, murine CD4(+) NKG2D(+) T cells were further classified into NK1.1(−) CD4(+) NKG2D(+) and NK1.1(+) CD4(+) NKG2D(+) subpopulations. The frequency of NK1.1(−) CD4(+) NKG2D(+) cells decreased in inflamed colons, whereas more NK1.1(+) CD4(+) NKG2D(+) cells infiltrated into colons of mice with DSS‐induced colitis. NK1.1(−) CD4(+) NKG2D(+) cells expressed TGF‐β and FasL without secreting IFN‐γ, IL‐21 and IL‐17 and displayed no cytotoxicity. The adoptive transfer of NK1.1(−) CD4(+) NKG2D(+) cells suppressed DSS‐induced colitis largely dependent on TGF‐β. NK1.1(−) CD4(+) NKG2D(+) cells did not expressed Foxp3, CD223 (LAG‐3) and GITR. The subpopulation was distinct from NK1.1(+) CD4(+) NKG2D(+) cells in terms of surface markers and RNA transcription. NK1.1(−) CD4(+) NKG2D(+) cells also differed from Th2 or Th17 cells because the former did not express GATA‐3 and ROR‐γt. Thus, NK1.1(−) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics.
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spelling pubmed-54879172017-07-04 NK1.1(−) CD4(+) NKG2D(+) T cells suppress DSS‐induced colitis in mice through production of TGF‐β Qian, Xingxing Hu, Chunxia Han, Sen Lin, Zhijie Xiao, Weiming Ding, Yanbing Zhang, Yu Qian, Li Jia, Xiaoqing Zhu, Guoqiang Gong, Weijuan J Cell Mol Med Original Articles CD4(+) NKG2D(+) T cells are associated with tumour, infection and autoimmune diseases. Some CD4(+) NKG2D(+) T cells secrete IFN‐γ and TNF‐α to promote inflammation, but others produce TGF‐β and FasL to facilitate tumour evasion. Here, murine CD4(+) NKG2D(+) T cells were further classified into NK1.1(−) CD4(+) NKG2D(+) and NK1.1(+) CD4(+) NKG2D(+) subpopulations. The frequency of NK1.1(−) CD4(+) NKG2D(+) cells decreased in inflamed colons, whereas more NK1.1(+) CD4(+) NKG2D(+) cells infiltrated into colons of mice with DSS‐induced colitis. NK1.1(−) CD4(+) NKG2D(+) cells expressed TGF‐β and FasL without secreting IFN‐γ, IL‐21 and IL‐17 and displayed no cytotoxicity. The adoptive transfer of NK1.1(−) CD4(+) NKG2D(+) cells suppressed DSS‐induced colitis largely dependent on TGF‐β. NK1.1(−) CD4(+) NKG2D(+) cells did not expressed Foxp3, CD223 (LAG‐3) and GITR. The subpopulation was distinct from NK1.1(+) CD4(+) NKG2D(+) cells in terms of surface markers and RNA transcription. NK1.1(−) CD4(+) NKG2D(+) cells also differed from Th2 or Th17 cells because the former did not express GATA‐3 and ROR‐γt. Thus, NK1.1(−) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics. John Wiley and Sons Inc. 2017-02-22 2017-07 /pmc/articles/PMC5487917/ /pubmed/28224733 http://dx.doi.org/10.1111/jcmm.13072 Text en © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Qian, Xingxing
Hu, Chunxia
Han, Sen
Lin, Zhijie
Xiao, Weiming
Ding, Yanbing
Zhang, Yu
Qian, Li
Jia, Xiaoqing
Zhu, Guoqiang
Gong, Weijuan
NK1.1(−) CD4(+) NKG2D(+) T cells suppress DSS‐induced colitis in mice through production of TGF‐β
title NK1.1(−) CD4(+) NKG2D(+) T cells suppress DSS‐induced colitis in mice through production of TGF‐β
title_full NK1.1(−) CD4(+) NKG2D(+) T cells suppress DSS‐induced colitis in mice through production of TGF‐β
title_fullStr NK1.1(−) CD4(+) NKG2D(+) T cells suppress DSS‐induced colitis in mice through production of TGF‐β
title_full_unstemmed NK1.1(−) CD4(+) NKG2D(+) T cells suppress DSS‐induced colitis in mice through production of TGF‐β
title_short NK1.1(−) CD4(+) NKG2D(+) T cells suppress DSS‐induced colitis in mice through production of TGF‐β
title_sort nk1.1(−) cd4(+) nkg2d(+) t cells suppress dss‐induced colitis in mice through production of tgf‐β
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487917/
https://www.ncbi.nlm.nih.gov/pubmed/28224733
http://dx.doi.org/10.1111/jcmm.13072
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