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The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial red...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488022/ https://www.ncbi.nlm.nih.gov/pubmed/28594389 http://dx.doi.org/10.3390/antiox6020042 |
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author | Chen, Chaofei Li, Li Zhou, Huanjiao Jenny Min, Wang |
author_facet | Chen, Chaofei Li, Li Zhou, Huanjiao Jenny Min, Wang |
author_sort | Chen, Chaofei |
collection | PubMed |
description | The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3) to scavenge H(2)O(2) in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions. It seems to be paradoxical for ROS-producing NOX4 and ROS-scavenging TRX2 to have a similar role in promoting angiogenesis. In this review, we will focus on data supporting the role of NOX4 and TRX2 in angiogenesis and their cross-talks and discuss how ROS can positively or negatively regulate angiogenesis, depending on their species, levels and locations. NOX4 and TRX2-mediated ROS signaling could be promising targets for the treatment of angiogenesis-related diseases. |
format | Online Article Text |
id | pubmed-5488022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54880222017-06-29 The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk Chen, Chaofei Li, Li Zhou, Huanjiao Jenny Min, Wang Antioxidants (Basel) Review The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3) to scavenge H(2)O(2) in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions. It seems to be paradoxical for ROS-producing NOX4 and ROS-scavenging TRX2 to have a similar role in promoting angiogenesis. In this review, we will focus on data supporting the role of NOX4 and TRX2 in angiogenesis and their cross-talks and discuss how ROS can positively or negatively regulate angiogenesis, depending on their species, levels and locations. NOX4 and TRX2-mediated ROS signaling could be promising targets for the treatment of angiogenesis-related diseases. MDPI 2017-06-08 /pmc/articles/PMC5488022/ /pubmed/28594389 http://dx.doi.org/10.3390/antiox6020042 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Chaofei Li, Li Zhou, Huanjiao Jenny Min, Wang The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk |
title | The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk |
title_full | The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk |
title_fullStr | The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk |
title_full_unstemmed | The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk |
title_short | The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk |
title_sort | role of nox4 and trx2 in angiogenesis and their potential cross-talk |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488022/ https://www.ncbi.nlm.nih.gov/pubmed/28594389 http://dx.doi.org/10.3390/antiox6020042 |
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