Instantaneous Conversion of [(11)C]CO(2) to [(11)C]CO via Fluoride‐Activated Disilane Species

The development of a fast and novel methodology to generate carbon‐11 carbon monoxide ([(11)C]CO) from cyclotron‐produced carbon‐11 carbon dioxide ([(11)C]CO(2)) mediated by a fluoride‐activated disilane species is described. This methodology allows up to 74 % conversion of [(11)C]CO(2) to [(11)C]CO...

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Detalles Bibliográficos
Autores principales: Taddei, Carlotta, Bongarzone, Salvatore, Gee, Antony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488231/
https://www.ncbi.nlm.nih.gov/pubmed/28419627
http://dx.doi.org/10.1002/chem.201701661
Descripción
Sumario:The development of a fast and novel methodology to generate carbon‐11 carbon monoxide ([(11)C]CO) from cyclotron‐produced carbon‐11 carbon dioxide ([(11)C]CO(2)) mediated by a fluoride‐activated disilane species is described. This methodology allows up to 74 % conversion of [(11)C]CO(2) to [(11)C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl‐(11)C]N‐benzylbenzamide was successfully synthesized from produced [(11)C]CO in up to 74 % radiochemical yield (RCY) and >99 % radiochemical purity (RCP) in ≤10 min from end of [(11)C]CO(2) delivery.

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