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A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines

Described herein is an effective and practical modular flow design for the meta‐selective C−H arylation of anilines. The design consists of four continuous‐flow modules (i.e., diaryliodonium salt synthesis, meta‐selective C−H arylation, inline copper extraction, and aniline deprotection) which can b...

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Autores principales: Gemoets, Hannes P. L., Laudadio, Gabriele, Verstraete, Kirsten, Hessel, Volker, Noël, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488246/
https://www.ncbi.nlm.nih.gov/pubmed/28543979
http://dx.doi.org/10.1002/anie.201703369
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author Gemoets, Hannes P. L.
Laudadio, Gabriele
Verstraete, Kirsten
Hessel, Volker
Noël, Timothy
author_facet Gemoets, Hannes P. L.
Laudadio, Gabriele
Verstraete, Kirsten
Hessel, Volker
Noël, Timothy
author_sort Gemoets, Hannes P. L.
collection PubMed
description Described herein is an effective and practical modular flow design for the meta‐selective C−H arylation of anilines. The design consists of four continuous‐flow modules (i.e., diaryliodonium salt synthesis, meta‐selective C−H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta‐arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and excellent purity without the need for column chromatography, and the residual copper content meets the standards for parenterally administered pharmaceutical substances.
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spelling pubmed-54882462017-07-21 A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines Gemoets, Hannes P. L. Laudadio, Gabriele Verstraete, Kirsten Hessel, Volker Noël, Timothy Angew Chem Int Ed Engl Communications Described herein is an effective and practical modular flow design for the meta‐selective C−H arylation of anilines. The design consists of four continuous‐flow modules (i.e., diaryliodonium salt synthesis, meta‐selective C−H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta‐arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and excellent purity without the need for column chromatography, and the residual copper content meets the standards for parenterally administered pharmaceutical substances. John Wiley and Sons Inc. 2017-05-22 2017-06-12 /pmc/articles/PMC5488246/ /pubmed/28543979 http://dx.doi.org/10.1002/anie.201703369 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Gemoets, Hannes P. L.
Laudadio, Gabriele
Verstraete, Kirsten
Hessel, Volker
Noël, Timothy
A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines
title A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines
title_full A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines
title_fullStr A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines
title_full_unstemmed A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines
title_short A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines
title_sort modular flow design for the meta‐selective c−h arylation of anilines
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488246/
https://www.ncbi.nlm.nih.gov/pubmed/28543979
http://dx.doi.org/10.1002/anie.201703369
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